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Showing result 1 - 5 of 64 swedish dissertations matching the above criteria.

  2. 1. Estrogen and Glucocorticoid Metabolism

    Author : Therése Andersson; Tommy Olsson; Cecilia Mattsson; Ingegerd Söderström; Jonas Burén; Agneta Holmäng; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 11β-Hydroxysteroid Dehydrogenase Type 1; Estrogen; Cortisol; Adipose tissue; Liver; Menopause; Ovariectomy; Adipocyte; Estrogen Receptor β; Endocrinology; Endokrinologi; medicin; Medicine;

    Abstract : Background: Cardiovascular disease (CVD) is the leading cause of death among women in Sweden. The risk of CVD increases rapidly after the menopause. A major contributing factor may be the redistribution of adipose tissue, from the peripheral to central depots, associated with menopause. READ MORE

  4. 2. Adipose tissue as an active organ : blood flow regulation and tissue-specific glucocorticoid metabolism

    Author : Jonas Andersson; Tommy Olsson; Stefan Söderberg; Sverker Jern; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 11β-hydroxysteroid dehydrogenase type 1; adipose tissue; autonomic nervous system; blood flow; cortisol; nitric oxide; weight loss.; medicin; Medicine;

    Abstract : Background: Despite advances in the treatment of atherosclerosis, cardiovascular disease is the leading cause of death worldwide. With the population getting older and more obese, the burden of cardiovascular disease may further increase. READ MORE

  5. 3. Glucocorticoid administration : studies on weight regulation and metabolic implications

    Author : Joanna Uddén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glucocorticoids; leptin; obesity; adipose tissue; PAI-1; UCP-2; cortisol; the metabolic syndrome; 11 beta-HSD; eating behaviour; weight gain.;

    Abstract : Long-term treatment with glucocorticoids induces weight gain and increased risk to develop obesity-related metabolic complications like insulin resistance, type 2 diabetes and cardiovascular disease. Glucocorticoids have been suggested to play a role in development of visceral fat accumulation. READ MORE

  6. 4. Hormonal Regulation of the Human CYP27A1 and CYP7B1 Genes

    Author : Wanjin Tang; Kjell Wikvall; Maria Norlin; Mats Gåfvels; Uppsala universitet; []
    Keywords : Pharmaceutical biochemistry; CYP27A1; CYP7B1; cholesterol; estrogen; androgen; prostate; glucocorticoid receptor; fetal development; Farmaceutisk biokemi;

    Abstract : CYP27A1 and CYP7B1 are widely expressed in various human tissues and are two key enzymes involved in the pathways for conversion of cholesterol to bile acids. Also, CYP27A1 is involved in bioactivation of vitamin D3 and CYP7B1 plays a role in 7alpha-hydroxylation of dehydroepiandrosterone and other steroids. READ MORE

  7. 5. Apoptosis Regulation in Multiple Myeloma

    Author : Lina Dimberg; Helena Jernberg Wiklund; Kenneth Nilsson; Marie Arsenian Henriksson; Uppsala universitet; []
    Keywords : Biomedicine; multiple myeloma; apoptosis; survival; IFN; Stat1; Stat3; IGF-I; RTK inhibitor; PPP; IAP; Fas CD95; dexamethasone; Biomedicin;

    Abstract : Multiple myeloma (MM) is a virtually incurable B cell malignancy of the bone marrow. One important part of tumor progression and an obstacle for successful therapy is resistance to apoptosis. To combat this resistance, the mechanisms of apoptosis and survival in MM must be better defined. READ MORE