Search for dissertations about: "glucocorticoid regulation"

Showing result 11 - 15 of 64 swedish dissertations containing the words glucocorticoid regulation.

  2. 11. Prevention of growth failure caused by glucocorticoid treatment

    Author : Yunhan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Children with chronic inflammation often suffer from growth failure and many of these children are treated with high doses of glucocorticoids (GCs). However, the underlying mechanisms of growth failure under conditions of chronic inflammation and the relative contributions of inflammation per se and commonly used GC treatment are still unknown. READ MORE

  4. 12. Chromatin structure and histone modifications in gene regulation

    Author : Carolina Åstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In the living cell, DNA is densely packed into a chromatin structure constituting nucleosomal arrays. One nucleosome core particle includes a disc shaped protein octamer consisting of pairs of histones H2A, H2B, H3 and H4. 146 bp of DNA is wrapped in almost two turns around this protein complex. READ MORE

  5. 13. Studies on antidepressant-mediated regulation of signal transduction

    Author : Hongshi Qi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Depression affects around 16% of the population at some point in their lives and major depressive disorder is a leading cause of disability worldwide. Depression is caused by an interaction of genetic and environmental factors, but the molecular and cellular mechanisms underlying its pathogenesis are not entirely clear. READ MORE

  6. 14. Gluco- and mineralocorticoid receptor regulation of regional brain neurotrophism

    Author : Anita Christiane Hansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Neurotrophins; BDNF; NT-3; bFGF; FGF receptor; immediate early genes; c-fos; antisense oligodeoxynucleotides; adrenalectomy; stress; glucocorticoids; mineralocorticoids; glucocorticoid receptor; mineralocorticoid; receptor in situ hybridization.;

    Abstract : Gluco- and mineralocorticoid hormones exert powerful actions on brain function and are important in the mediation of the stress response and the survival of hippocampal neurons. The aim of this thesis was to study the influence of glucocorticoid (GR)/mineralocorticoid receptor (MR) actions on brain neurotrophism including analyses of immediate early genes (IEGs) and of feedback responses on GR and/or MR. READ MORE

  7. 15. Transcription factor effects on chromatin organisation and gene regulation

    Author : Per-Henrik Holmqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Chromatin; enhanceosome; MMTV; GR; NF1; Oct1; FoxA;

    Abstract : The intranuclear DNA of all eukaryotic cells is packed into chromatin, generating a repressive environment for the genome. Remodelling of the local chromatin structure is a vital process that allows access to the obscured DNA sequence and may induce the expression of specific genes. READ MORE