Search for dissertations about: "glucocorticoid regulation"

Showing result 6 - 10 of 64 swedish dissertations containing the words glucocorticoid regulation.

  2. 6. Alterations in peripheral glucocorticoid metabolism : effects of weight changes

    Author : Kotryna Simonyté; Cecilia Mattsson; Bo Angelin; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 11ß Hydroxysteroid dehydrogenase 1; obesity; glucocorticoids; cortisol; phosphoenolpyruvate carboxykinase; adipose tissue; liver; Endocrinology; Endokrinologi; medicin; Medicine;

    Abstract : Background: An important role has been suggested for tissue-specific glucocorticoid metabolism in the development of obesity and its complications. 11ß hydroxysteroid dehydrogenase 1 (11ßHSD1) is an enzyme that catalyzes the interconversion of biologically inactive cortisone to active cortisol, thereby regulating its access to glucocorticoid receptors in target tissues. READ MORE

  4. 7. Chromatin remodelling and gene regulation

    Author : Birgitta Gelius; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chromatin plays an important role in gene regulation, as it forms an obstacle for a number of proteins that need access to the DNA. Several protein complexes that open up the chromatin structure have been identified and some of these are important for gene regulation. READ MORE

  5. 8. Post-Transcriptional Regulation of the Murine Inducible Nitric Oxide Synthase Gene

    Author : Malin Söderberg; Matti A. Lang; Françoise Raffalli-Mathieu; Eeva Moilanen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; iNOS; inducible nitric oxide synthase; gene regulation; post-transcriptional; mRNA stability; RNA-protein interactions; dexamethasone; murine; heterogeneous nuclear ribonucleoprotein; hnRNPI; hnRNPL; Farmaceutisk biokemi; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Abstract : Large amounts of nitric oxide (NO) are produced by the inducible nitric oxide synthase (iNOS) upon inflammatory stimuli. NO is a multifaceted molecule, which may have beneficial effects as an antimicrobial agent in the immune defense, or cytotoxic effects in chronic inflammations, manifested as e.g. arthritis and asthma. READ MORE

  6. 9. Individual glucocorticoid sensitivity in the human

    Author : Urban Knutsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : hypothalamic-pituitary-adrenal axis; cortisol; dexamethasone suppression test; adrenocorticotropin stimulation test; glucocorticoid receptor mRNA; Metallothionein mRNA;

    Abstract : The expanding use of inhaled and intranasal glucocorticoid (Gc) preparations for treatment of mild-to-moderate asthma and allergic rhinitis has in the last decade greatly increased the number of adults and children chronically exposed to exogenous glucocorticoids. In general, current topical glucocorticoid therapies appear to be well tolerated. READ MORE

  7. 10. Gene regulation by the glucocorticoid receptor : post-DNA binding mechanisms of transcriptional activation

    Author : Tova Almlöf; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Gene activation; Glucocorticoid receptor; Nuclear receptor; Transactivation domain; Transcription; Transcription factor; Yeast;

    Abstract : The glucocorticoid receptor (GR) is a ligand-inducible transcription factor that belongs to the nuclear receptor family. The GR has important functions in cellular differentiation, development and metabolism in higher eukaryotes. READ MORE