Search for dissertations about: "glucocorticoids lung"

Showing result 1 - 5 of 15 swedish dissertations containing the words glucocorticoids lung.

2. 1. Lung mechanics and airway inflammation in murine models of asthma

   Author : Sofia Jonasson; Josephine Hjoberg; Hedenstierna Göran; Carl Persson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allergic asthma; airway inflammation; murine models; lung mechanics; forced oscillation technique; airway reactivity; deep inhalations; oxidative stress; nitric oxide; glucocorticoids.; Clinical physiology; Klinisk fysiologi; klinisk fysiologi; Clinical Physiology;

   Abstract : Allergic asthma is an inflammatory disease of the airways and is characterized by eosinophilic inflammation and increased airway reactivity. In the studies presented in this thesis, lung mechanics and measurements of airway reactivity were assessed in anaesthetized tracheostomized mice by using an animal ventilator (flexiVent®). READ MORE

4. 2. Effects of Asthma Combination Therapy on Extracellular Matrix Remodeling in Human Lung Fibroblasts

   Author : Lizbet Todorova; Lungbiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma; Proteoglycans; Lung fibroblasts; Collagen; Airway remodeling; TGFβ; Glucocorticoids; Combination therapy.; β2-agonist; MMPs;

   Abstract : Fibroblasts, being one of the resident and structural cells of the lung, have the capacity to produce inflammatory mediators, cytokines and extracellular matrix (ECM) proteins perpetuating the inflammation in the airways of asthmatics. Airway remodeling is also a prominent feature of asthma that affects the lung function causing a thickening of the airways. READ MORE

5. 3. Development and Resolution of Allergic Airway Inflammation in vivo: effects of therapeutic intervention

   Author : Lena Uller; Lungbiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Andningsorganen; Respiratory system; Medicin människa och djur ; Medicine human and vertebrates ; Animal models; Glucocorticoids; Eosinophils; Apoptosis; Asthma; Allergy;

   Abstract : Eosinophils, containing tissue toxic granule proteins, are regarded a culprit cell in asthma pathogenesis. Using animal and human experimental models of asthma effects on eosinophilic airway inflammation were investigated in vivo. READ MORE

6. 4. Studies on the deposition, bioavailability and systemic activity of glucocorticoids in man

   Author : Lars Thorsson; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacological sciences; systemic activity; glucocorticosteroids; lung deposition; systemic availability; inhalation; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Abstract : The local deposition, pharmacokinetics, and systemic activity of inhaled and intranasal glucocorticosteroids in different formulations and devices(ICSs) has been investigated. After nasal administration of the ICS budesonide (Bud), the systemic availability (F) was found to be significantly higher from an aqueous pump spray and from the powder inhaler Turbuhaler, than from a pressurized metered dose inhaler (pMDI), and the uptake process was slower and less complete with the pMDI formulation. READ MORE

7. 5. C/EBP transcription factors in lung cellular differentiation and development

   Author : Tove Berg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : C EBP transcription factors; lung; development; differentiation; glucocorticoid regulation;

   Abstract : During embryonic development the lung is lined with a primitive epithelium. As development proceeds, the epithelium matures and differentiates into several cell types that together with cells of mesenchymal origin constitute the adult lung. READ MORE