Search for dissertations about: "glucuronidase"

Showing result 1 - 5 of 9 swedish dissertations containing the word glucuronidase.

  2. 1. Influence of probiotics and other external factors on intestinal biochemical microflora-associated characteristics : studies in vitro and in vivo in gnotobiotic mice and in pigs

    Author : Maria E Cardona G; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Gastrointestinal microflora germ-free mice; lactic acid bacteria; microflora- associated characteristics; piglets; probiotics.;

    Abstract : The benefit of harboring a balanced intestinal microflora is well recognized. Therefore, in order to 'maintain or improve the intestinal flora, the use of microbial species as feed supplements, i.e. probiotics, has rapidly increased. READ MORE

  4. 2. Roles of Heparan Sulfate in Amyloid-β Pathology and Hypoxia

    Author : Elina Hjertström; Jin-ping Li; Ulf Lindahl; Sally Stringer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparan sulfate; Alzheimer s disease; Aβ; Proteoglycan; Heparanase; Amyloid; Hypoxia; Cancer; Spalax; Biochemistry; Biokemi; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Heparan sulfate (HS) is a highly sulfated polysaccharide expressed on the cell surface and in the extracellular matrix, interacting with a large number of proteins. HS is implicated in human diseases, including different types of cancer and amyloid diseases such as Alzheimer's disease (AD). READ MORE

  5. 3. Understanding Heparan Sulfate Biosynthesis and Functional Implications of Heparanase

    Author : Tianyi Song; Dorothe Spillmann; Cathrine Merry; Uppsala universitet; []
    Keywords : Heparan sulfate; biosynthesis; heparanase; lipid metabolism; cancer; cell adhesion; apoptosis.; Molekylär medicin;

    Abstract : Heparan sulfate (HS) proteoglycans are present on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Heparanase is an endo-ß-glucuronidase that cleaves HS chains at internally located ß-glucuronidic linkages1. READ MORE

  6. 4. Structural Determination of Drug Metabolites from Doping Classed Compounds Using Mass Spectrometry

    Author : Annelie Hansson; Mikael Hedeland; Ulf Bondesson; Peter Hemmersbach; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry; UHPLC-MS MS; doping control; Cunninghamella elegans; selective androgen receptor modulator; SARM; andarine; ostarine; LGD-4033; roxadustat; HIF stabilizer; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : Doping control in equine sports is important for a fair competition, but also to ensure the integrity of the betting system, as well as for animal welfare reasons. To detect the use of illicit compounds, screening for the parent compound is common. However, by using a metabolite as the analytical target instead, the detection time can be prolonged. READ MORE

  7. 5. Cellular mechanisms involved in bone resorption

    Author : Ulf Lerner; Umeå universitet; []
    Keywords : Bone resorption. cyclic AMP; parathyroid hormone; prostaglandins; la OH D3; lysosomal enzyme release; osteoclast; periodontitis; rheumatoid arthritis;

    Abstract : The effects of parathyroid hormone (PTH), prostaglandins (PGE1, PGE2, PGF2a), cAMP, cAMP-analogues, phosphodiesterase (PDE) inhibitors and la (OH) D3 on bone resorption and associated cellular process have been studied in a bone organ culture system using half- calvaria from 6-7 day-old mice. Bone resorption was assessed by determining the release of calcium (Ca2+), inorganic phosphate (Pi) and 45Ca from the calvarial bones to the culture media. READ MORE