Search for dissertations about: "glutathionylation"
Showing result 1 - 5 of 9 swedish dissertations containing the word glutathionylation.
-
1. Novel methods for the identification of cellular S-glutathionylated proteins and sites of glutathionedependent modification using affinity chromatography and proteomic analyses
Abstract : Reactive oxygen species (ROS) are formed during normal respiration in the mitochondria through electron leakage to oxygen. During normal metabolism, several enzymes and low-molecular weight antioxidants work towards eliminating ROS in a well-coordinated manner. READ MORE
-
2. Urocortins in the zebrafish brain and redox regulation of embryonic development through glutaredoxins
Abstract : The cellular redox state is a central regulator of embryonic development. Redox homeostasis and thiol redox signaling are modulated through glutaredoxins (Grxs), glutathione dependent thiol-disulfide oxidoreductases. Grxs can reduce protein disulfides and protein-glutathione mixed disulfides (de-glutathionylation) via distinct reaction mechanisms. READ MORE
-
3. Development and biomedical applications of highly sensitive enzyme activity assays of thioredoxin, thioredoxin reductase and glutaredoxin
Abstract : Oxidative stress is implicated in the pathogenesis of many human diseases, thus it is interesting to study the relationship between antioxidants, the development and progression of diseases. The thioredoxin and glutaredoxin systems are ubiquitous redox-active proteins known to be induced in chronic inflammatory related processes, such as cancer and diabetes, to protect against oxidative stress. READ MORE
-
4. Characterization and function of Escherichia coli glutaredoxins
Abstract : Escherichia coli employs two separate pathways, driven by NADPH to reduce protein disulfides: the thioredoxin and glutaredoxin systems. Both systems function via redox active disulfides and are involved in many cellular functions including, the synthesis of DNA building blocks (by reducing the essential enzyme ribonucleotide reductase), the generation of reduced sulfur (via PAPS reductase), and the repair of oxidative damage to protein (by methionine sulfoxide reductase). READ MORE
-
5. Structure and function in c-Myc and Grx4 : two key proteins involved in transcriptional activation and oxidative stress
Abstract : The proto-oncogene c-myc is critical for growth and development and deregulation of c-myc expression affects the initiation and expansion of a wide range of human cancers, many of them aggressive. cMyc is a multi-domain protein, where it's C-terminal basic helix-loop-helix leucine zipper (bHLH-Zip) domain heterodimerizes with Max to accomplish gene regulatory activity. READ MORE