Search for dissertations about: "glycosylation"

Showing result 11 - 15 of 166 swedish dissertations containing the word glycosylation.

  1. 11. Development and Application of Proximity Assays for Proteome Analysis in Medicine

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Felipe Marques Souza de Oliveira; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solid-phase proximity ligation assay; post-translational modifications; glycosylation; phosphorylation; Enzyme-linked immunosorbent assay; immunoassay and rolling circle amplification; Proximity Extension Assay; inflammation protein biomarkers; autoantibodies; autoimmune disease;

    Abstract : Along with proteins, a myriad of different molecular biomarkers, such as post-translational modifications and autoantibodies, could be used in an attempt to improve disease detection and progression. In this thesis, I build on several iterations of the proximity ligation assay to develop and apply new adaptable methods to facilitate detection of proteins, autoantibodies and post-translational modifications. READ MORE

  2. 12. Intrapatient evolution of HIV-1 in the context of coreceptor usage

    University dissertation from Lund University, Faculty of Medicine Doctoral Dissertation Series

    Author : Mattias Mild; Lunds universitet.; Lund University.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coreceptor switch; Medicine human and vertebrates ; Medicin människa och djur ; biological cloning; R5-X4; coreceptor usage; glycosylation; recombination; HIV; evolution;

    Abstract : The variable region 1 to 3 (V1-V3) of the HIV-1 envelope plays an important role in coreceptor usage. Early in infection HIV- 1 is using CCR5 as coreceptor to enter target cells (R5 viruses) whereas viruses using CXCR4 as coreceptor (X4 viruses) may appear later in infection. READ MORE

  3. 13. Clusterin in brain and cerebrospinal fluidin Alzheimer s disease

    University dissertation from Lund University, Faculty of Medicine Doctoral Dissertation Series

    Author : Anna-Maria Nilselid; Göteborgs universitet.; Gothenburg University.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; clusterin; apolipoprotein J; SP-40; brain tissue; cerebrospinal fluid; glycosylation; biomarker; enzyme-linked immunosorbent assay;

    Abstract : The apolipoprotein clusterin is suggested to be involved in the pathogenesis of Alzheimer¡¦s disease (AD). At the start of these studies, results had indicated that clusterin was elevated in AD brain, compared with controls. READ MORE

  4. 14. Implications of Local Puumala Hantavirus Genetics and Epidemiology for Diagnostics and Vaccine Development

    University dissertation from Umeå : Klinisk mikrobiologi

    Author : Patrik Johansson; Umeå universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; hantavirus; Puumala virus; nephropathia epidemica; genome sequence; glycosylation; linear DNA vaccine; microarray; identification; genetic variability; Infektionssjukdomar; MEDICINE Microbiology; immunology; infectious diseases Infectious diseases; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Infektionssjukdomar; medicinsk virologi; Medical Virology;

    Abstract : Puumala viruses, a member of the Hantavirus genus in the Bunyaviridae family, are enveloped by a lipid bilayer and possesses a tripartite single stranded RNA genome with negative polarity. The hantaviruses encode four proteins: a nucleocapsid protein (N), two membrane spanning glycoproteins (GN and GC) and a RNA dependent RNA polymerase (RdRp). READ MORE

  5. 15. Synthesis of Bacterial Oligosaccharides from N. meningitidis and Mechanistic Details of Stereoselective Glycosylations Using a Novel Bicyclic Donor

    University dissertation from Stockholm : Department of Organic Chemistry, Stockholm University

    Author : Johan Olsson; Stockholms universitet.; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; oligosaccharide synthesis; heptose; thioglycoside; glycosylation; Neisseria meningitidis; 2; 3-oxazolidinone; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : This thesis includes two parts. The first part, comprising Chapters 3, 4 and 5, describes the synthesis of bacterial oligosaccharides. In Chapters 3 and 4, the synthesis of branched and phosphorylated oligosaccharide structures corresponding to inner core epitopes of the lipopolysaccharide (LPS) of the Gram-negative bacteria N. READ MORE