Search for dissertations about: "glycosylation"

Showing result 31 - 35 of 192 swedish dissertations containing the word glycosylation.

  2. 31. Conformational Stability!? : Synthesis and Conformational Studies of Unnatural Backbone Modified Peptides

    Author : Anna S. Norgren; Per I. Arvidsson; Norbert Sewald; Uppsala universitet; []
    Keywords : Organic chemistry; Conformational investigations; β-peptides; glycosylation; biomolecular recognition; cyclic β³-peptides; cyclic mixed α β²-peptides; β-peptoids; Organisk kemi;

    Abstract : The beauty of the wide functionality of proteins and peptides in Nature is determined by their ability to adopt three-dimensional structures. This thesis describes artificial molecules developed to mimic secondary structures similar to those found crucial for biological activities. READ MORE

  4. 32. Helicobacter spp. interactions with mucins: adhesion and mucin regulation of pathogen proliferation and gene expression

    Author : Emma C Skoog; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Helicobacter; mucin; glycosylation; Lactobacillus; adhesion; proliferation; gene expression; CagA; SabA; BabA; ArsS; Fur;

    Abstract : Helicobacter pylori colonizes the gastric mucosa of approximately half of the world’s population and is a risk factor for gastritis, peptic ulcers and gastric cancer. H. pylori is surrounded by, and adheres to, the heavily glycosylated mucins that build up the mucus layer. The carbohydrate structures on the mucins that act as ligands for H. READ MORE

  5. 33. Glycoconjugates : synthesis and investigation of carbohydrate-protein interactions

    Author : Sara Spjut; Mikael Elofsson; Ulf Ellervik; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugates; Carbohydrates; Galactose; Glucose; Solid-phase synthesis; SPOS; Glycosylation; Gel-phase 19F NMR spectroscopy; Fluorinated linker; Carbohydrate array; Microtiter plates; Carbohydrate-protein interactions; carbamate linker; Fsec; Protecting group; Fluorinated protecting group; Multivalent glycoconjugates; Adenovirus; Ad37; Epidemic keratoconjunctivitis; EKC; Sialic acid; Adenovirus inhibitor; Trivalent; Tetravalent; X-ray crystal structure; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry;

    Abstract : To study the functions of glycoconjugates in biological systems reliable and efficient protocols for glycoconjugate synthesis are needed. To reach this goal we have developed methods for solid-phase synthesis of glycoconjugates that can be monitored with gel-phase 19F spectroscopy using fluorinated linkers, building blocks, and protecting groups. READ MORE

  6. 34. Enzymatic Synthesis of Alkyl Glycosides. New Applications for Glycoside Hydrolases

    Author : David Svensson; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; CGTase; cyclodextrin glycosyltransferase; alkyl glycoside; enzyme stabliity; enzymatic synthesis; enzyme immobilisation; surfactant; glycosylation;

    Abstract : The environmental problems caused by human interventions, such as the consumption of non-renewable resources and the emission of greenhouse gases are well-recognised. Calls have been made for immediate measures to develop more sustainable society worldwide. READ MORE

  7. 35. Glycosylation in cancer and infection : the role of sialic acid

    Author : Yuecheng Zhang; Anette Wingren; Maria Stollenwerk; Lars Ohlsson; Martin Dufva; Malmö universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer; sialic acids; receptor; molecularly imprinted polymers; SARS-CoV-2; fluorescence; Health and society; Hälsa och samhälle;

    Abstract : Sialic acids (SA), a group of nine-carbon backbone monosaccharides are abundantly expressed in vertebrates. They are usually linked to the terminal of glycan chains and play crucial roles in many biological processes, including cell adhesion, cell-cell interactions, immune modulation, cancer cell migration and invasion, as well as viral infections. READ MORE