Search for dissertations about: "glyoxalase I"

Showing result 1 - 5 of 8 swedish dissertations containing the words glyoxalase I.

  2. 1. Studies on glyoxalase I from erythrocytes

    Author : Anne-Charlotte Aronsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The aim of this investigation was to achieve an increased understanding of the properties of glyoxalase I, in order to eventually elucidate the physiological functions of the enzyme. Glyoxalase I was purified to homogeneity by a procedure involving affinity chromatography. READ MORE

  4. 2. Computational Studies of Enzymatic Enolization Reactions and Inhibitor Binding to a Malarial Protease

    Author : Isabella Feierberg; Modesto Orozco; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Theoretical chemistry; enzyme mechanism; enolate; molecular dynamics; empirical valence bond; glyoxalase I; ketosteroid isomerase; triosephosphate isomerase; malaria; aspartic protease; plasmepsin; linear interaction energy; drug design; Teoretisk kemi; Theoretical chemistry; Teoretisk kemi; Molecular Biotechnology; Molekylär bioteknik;

    Abstract : Enolate formation by proton abstraction from an sp3-hybridized carbon atom situated next to a carbonyl or carboxylate group is an abundant process in nature. Since the corresponding nonenzymatic process in water is slow and unfavorable due to high intrinsic free energy barriers and high substrate pKa s, enzymes catalyzing such reaction steps must overcome both kinetic and thermodynamic obstacles. READ MORE

  5. 3. The steady-state kinetics of glyoxalase I from yeast and porcine erythrocytes : the use of regression methods in discrimination between rival models

    Author : Tamas Bartfai; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE

  6. 4. The use of metal substitution in characterizing the catalytic mechanism of glyoxalase I

    Author : Siv Sellin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Glyoxalase I, a zinc enzyme, has been purified from human erythrocytes. The aim of this investigation was to examine the active center of this enzyme and its catalytic mechanism by applying different spectroscopic methods to the study of metal-substituted glyoxalase I. READ MORE

  7. 5. A comparison of the structure and function of glyoxalase I from yeast and mammals

    Author : Ewa Marmstål; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE