Search for dissertations about: "glyoxalase I"

Found 3 swedish dissertations containing the words glyoxalase I.

  1. 1. Computational Studies of Enzymatic Enolization Reactions and Inhibitor Binding to a Malarial Protease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Isabella Feierberg; Uppsala universitet.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Theoretical chemistry; enzyme mechanism; enolate; molecular dynamics; empirical valence bond; glyoxalase I; ketosteroid isomerase; triosephosphate isomerase; malaria; aspartic protease; plasmepsin; linear interaction energy; drug design; Teoretisk kemi; NATURAL SCIENCES Chemistry Theoretical chemistry; NATURVETENSKAP Kemi Teoretisk kemi; Molecular Biotechnology; Molekylär bioteknik;

    Abstract : Enolate formation by proton abstraction from an sp3-hybridized carbon atom situated next to a carbonyl or carboxylate group is an abundant process in nature. Since the corresponding nonenzymatic process in water is slow and unfavorable due to high intrinsic free energy barriers and high substrate pKa s, enzymes catalyzing such reaction steps must overcome both kinetic and thermodynamic obstacles. READ MORE

  2. 2. Quantum Chemical Modeling of Binuclear Zinc Enzymes

    University dissertation from Stockholm : KTH

    Author : Shilu Chen; KTH.; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Quantum Chemical Modeling; Binuclear; Zinc; Enzyme; DFT; Mechanism; NATURAL SCIENCES Chemistry Theoretical chemistry; NATURVETENSKAP Kemi Teoretisk kemi;

    Abstract : In the present thesis, the reaction mechanisms of several di-zinc hydrolases have been explored using quantum chemical modeling of the enzyme active sites. The studied enzymes are phosphotriesterase (PTE), aminopeptidase from Aeromonas proteolytica (AAP), glyoxalase II (GlxII), and alkaline phosphatase (AP). READ MORE

  3. 3. Exploring the Functional Plasticity of Human Glutathione Transferases Allelic Variants, Novel Isoenzyme and Enzyme Redesign

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ann-Sofie Johansson; Uppsala universitet.; [2002]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; biokemi; Biochemistry;

    Abstract : Glutathione transferases (GSTs) make up a superfamily that is involved in the cellular defense against various reactive compounds by catalyzing the conjugation of glutathione to electrophilic centra. Members of this family have also been implicated in different facets of biological signaling. READ MORE