Search for dissertations about: "golgi"

Showing result 1 - 5 of 109 swedish dissertations containing the word golgi.

  2. 1. Functional characterization of the secretory pathway and the role of COPI vesicles

    Author : Johan Hiding; Göteborgs universitet; []
    Keywords : Golgi; Phosphoinositides; Fusion; COPI; ARF1; Proteomics; ER;

    Abstract : In the secretory pathway, proteins synthesized in the endoplasmatic reticulum move through the Golgi apparatus in a cis-to-trans direction and then sorts into different types of vesicles at the trans-Golgi network. How intracellular transport takes place has been the focus of cell biology research for a long time. READ MORE

  4. 2. Analysis of Binding Events and Diffusion in Living Cells

    Author : Markus Elsner; Göteborgs universitet; []
    Keywords : COPI; Golgi; Diffusion; Glycosyltransferases; Sorting; Molecular; Crowding;

    Abstract : It is well known that diffusion is the main mode of transport in living cells, but the consequences of diffusion in a complex cellular environment are not generally appreciated. In this thesis, we have investigated several aspects of how diffusion properties influence the observability of cellular binding kinetics and how they can be used to obtain information about the environment of proteins and other molecules. READ MORE

  5. 3. Haptoglobin: Biosynthesis and Evolution

    Author : Krzysztof B. Wicher; Erik Fries; John W. M. Creemers; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; haptoglobin; cleavage; C1r-LP; evolution; vertebrate; endoplasmic; Golgi; complement; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Abstract : Haptoglobin (Hp) is a serum protein known for its ability to form a tight complex with hemoglobin (Hb) and thereby inhibiting the oxidative activity of Hb. Mammalian Hp is synthesized as a precursor (proHp) that undergoes proteolytic cleavage by a previously unidentified enzyme in the endoplasmic reticulum (ER). READ MORE

  6. 4. Cellular design of heparan sulfate : The NDST enzymes and their regulation

    Author : Pernilla Carlsson; Lena Kjellén; Tarja Kinnunen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; heparan sulfate; heparin; proteoglycan; NDST; PAPS; Golgi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Heparan sulfate proteoglycans are proteins with long, unbranched heparan sulfate (HS) polysaccharide chains attached to them. They are found on cell surfaces and in basement membranes where they exert their action by interacting with a wide range of enzymes and signaling molecules and are thereby involved in a range of various processes both during embryonic development and in adult physiology. READ MORE

  7. 5. Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth

    Author : Anna Schultz; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; oncology; cancerology; Cytologi; Prostate Cancer; Neuroblastoma; Ceramide; Golgi Apparatus; Neurite outgrowth; Apoptosis; Protein Kinase C; C1 domain;

    Abstract : Protein kinase C (PKC) is a family of serine/threonine kinases, which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. One major aim of this thesis work was to investigate if altered levels of PKC isoforms influence the apoptotic responses of malignant cell-lines. READ MORE