Search for dissertations about: "gp160"

Showing result 1 - 5 of 8 swedish dissertations containing the word gp160.

  1. 1. Variable viral genes as genetic immunogens

    Author : Karl Ljungberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Influenza; hemagglutinin; HIV-1; gp160; DNA vaccine; genetic immunization; CpG; GM-CSF; pseudovirus.;

    Abstract : Influenza and HIV-1 are two highly variable viruses that cause extensive morbidity and mortality in many countries. The most cost- effective medical intervention against influenza is vaccination but this has to be repeated annually because of the low antigenicity of the vaccine. READ MORE

  2. 2. Immune and autoimmune responses to HIV-1 in mucosa and other tissues

    Author : Peter Lundholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The aim of these studies was to evaluate routes and devices for administration of HIV-1 DNA vaccines. In particular we were interested in mucosal routes for the induction of immunity at mucosal surfaces. We studied the effects of a novel mucosal route, jet-injection, for induction of systemic and local responses. READ MORE

  3. 3. Evaluation of HIV testing strategies and monitoring of immune responses in HIV-vaccinated individuals in Tanzania

    Author : Said Aboud; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : This thesis describes studies on the evaluation of human immunodeficiency virus (HIV) enzyme-linked immunosorbent assays (ELISAs) and simple rapid HIV assays for use in HIV testing strategies in resource-limited settings and studies of HIV vaccine-induced immune responses. Peripheral blood mononuclear cell (PBMC) preparation techniques were also studied in preparation for use in the HIV vaccine trials. READ MORE

  4. 4. Immune responses induced by immunization with HIV-1 DNA followed by HIV-modified vaccinia virus Ankara with or without recombinant GP140 in healthy Tanzanian individuals

    Author : Agricola Joachim; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : A vaccine against HIV is widely considered the most effective and sustainable way of preventing new infections. We previously conducted a phase I/II clinical trial using multi-clade, multigene HIV-DNA priming and boosting with the recombinant modified vaccinia Ankara (HIV-MVA) virus among healthy Tanzanian volunteers (HIVIS03 trial). READ MORE

  5. 5. Co-evolution of the HIV-1 R5 phenotype and the viral envelope glycoproteins

    Author : Johanna Repits; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; envelope; R5; HIV-1; evolution;

    Abstract : To gain entry into target cells, HIV-1 binds to CD4 via the viral glycoprotein gp120. This interac-tion initiates a series of events including binding of a coreceptor, CCR5 and/or CXCR4, and ulti-mately leads to gp41-mediated fusion of the viral and cell membranes. READ MORE