Search for dissertations about: "gp160"

Showing result 1 - 5 of 9 swedish dissertations containing the word gp160.

  2. 1. Variable viral genes as genetic immunogens

    Author : Karl Ljungberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Influenza; hemagglutinin; HIV-1; gp160; DNA vaccine; genetic immunization; CpG; GM-CSF; pseudovirus.;

    Abstract : Influenza and HIV-1 are two highly variable viruses that cause extensive morbidity and mortality in many countries. The most cost-effective medical intervention against influenza is vaccination but this has to be repeated annually because of the low antigenicity of the vaccine. READ MORE

  4. 2. Altering HIV-1 envelope glycoprotein maturation and its effects on viral infectivity

    Author : Alenka Jejcic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1;

    Abstract : HIV-1 is dependent on its envelope glycoprotein (Env) to initiate infection. Env binds to cellular receptors and mediate the following fusion of the viral envelope with the cell plasma membrane. READ MORE

  5. 3. Immune and autoimmune responses to HIV-1 in mucosa and other tissues

    Author : Peter Lundholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of these studies was to evaluate routes and devices for administration of HIV-1 DNA vaccines. In particular we were interested in mucosal routes for the induction of immunity at mucosal surfaces. We studied the effects of a novel mucosal route, jet-injection, for induction of systemic and local responses. READ MORE

  6. 4. Evaluation of HIV testing strategies and monitoring of immune responses in HIV-vaccinated individuals in Tanzania

    Author : Said Aboud; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis describes studies on the evaluation of human immunodeficiency virus (HIV) enzyme-linked immunosorbent assays (ELISAs) and simple rapid HIV assays for use in HIV testing strategies in resource-limited settings and studies of HIV vaccine-induced immune responses. Peripheral blood mononuclear cell (PBMC) preparation techniques were also studied in preparation for use in the HIV vaccine trials. READ MORE

  7. 5. Immune responses induced by immunization with HIV-1 DNA followed by HIV-modified vaccinia virus Ankara with or without recombinant GP140 in healthy Tanzanian individuals

    Author : Agricola Joachim; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A vaccine against HIV is widely considered the most effective and sustainable way of preventing new infections. We previously conducted a phase I/II clinical trial using multi-clade, multigene HIV-DNA priming and boosting with the recombinant modified vaccinia Ankara (HIV-MVA) virus among healthy Tanzanian volunteers (HIVIS03 trial). READ MORE