Search for dissertations about: "granzyme B"

Showing result 16 - 20 of 35 swedish dissertations containing the words granzyme B.

  2. 16. Characterisation of CD8 T cells in mucosa associated lymphoid tissue : implications for immune control of HIV-1 infection

    Author : Máire Quigley; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CD8 T cells; Human Immunodeficiency Virus-1; Mucosa Associated Lymphoid Tissue; perforin; cytotoxicity; gastrointestinal mucosa; tonsil; CD7 expression; Simian Immunodeficiency Virus.;

    Abstract : The role of CD8 T cells has been implicated in the partial immune control of HIV-1 infection. Ultimately these cells fail to control the infection and immune deficiency ensues in the absence of antiretroviral therapy. READ MORE

  4. 17. Clinical and immunopathological studies in Hodgkin's disease with special reference to prognosis

    Author : Ulla Axdorph; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hodgkin's disease (HD) and non-Hodgkin lymphoma (NHL) have certain features in common, but also distinct clinical and pathological differences. Thus, HD has many features of both an infectious (fever, leukocytosis, eosinophilia, night sweats, lymphadenopathy, splenomegaly) and a malignant process with few tumour cells, T-cell accumulation and sclerosis. READ MORE

  5. 18. Laboratory methods for investigation of the immunological orchestra in response to pathogens

    Author : Hanna Carlsson; Ivar Tjernberg; Christina Ekerfelt; Kristina Nilsson Ekdahl; Jorma Hinkula; Matti Sällberg; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Borrelia; Influenza; Immunology; Immune response; Cellmediated; Serological; Subclinical; ELISA; Luminex; Proximity extension assay;

    Abstract : Laboratory methods used for investigation of immune response often involve collection of whole blood and analysis of different biomarkers in blood components or generated from pathogen stimulation of whole blood or peripheral blood mononuclear cells (PBMC). Methods used to measure biomarkers are for example enzyme-linked immunosorbent assay (ELISA) which measures one biomarker at a time or multiplex assays for example x-unknown, multi-analyte profiling (xMAP) by Luminex or proximity extension assay (PEA), which can measure up to just over 3000 biomarkers at a time. READ MORE

  6. 19. Understanding cellular and cytoskeletal dysregulation in immunodeficiency diseases

    Author : Anton Sendel; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The immune system is a complex network of cells and molecules interacting to preserve the integrity and survival of the host by distinguishing self from non-self, and dysregulation of immune cells can lead to immunodeficiency, autoimmunity, and cancer. The cytoskeleton is essential for several important immune cell functions, including proliferation, movement, signaling, and vesicle trafficking. READ MORE

  7. 20. Induction of Mast Cell Apoptosis via Granule Permeabilization : A Novel Approach to Target Mast Cells

    Author : Aida Paivandy; Gunnar Pejler; Magda Babina; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mast cells; Granules; Apoptosis; Reactive oxygen species; ROS; Lysosomotropic agents; Mefloquine; Immunologi; Immunology; Biokemi; Biochemistry;

    Abstract : Mast cells are densely granulated tissue-resident immune cells that play an important role in orchestrating inflammatory responses. Dysregulated increases in the numbers and activation status of mast cells can have deleterious consequences for the body in various inflammatory diseases. READ MORE