Search for dissertations about: "granzyme B"

Showing result 6 - 10 of 35 swedish dissertations containing the words granzyme B.

  2. 6. Molecular monitoring of acute graft-versus-host disease after allogenic stem cell transplantation

    Author : Marie Jaksch; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Stem Cell Transplantation; Acute Graft-versus-host disease; FasL; Granzym B; Chemokine receptors; chimerism;

    Abstract : Acute graft-versus-host disease (GVHD) remains a major barrier to the wider application of allogeneic stem cell transplantation (SCT) for a variety of diseases. GVHD occurs when the transplanted donor Tlymphocytes react to host antigens on antigen-presenting cells and attack host tissues. READ MORE

  4. 7. On the role of Natural Killer cell immunogenetics for the outcome of immunotherapy in acute myeloid leukemia

    Author : Brwa Ali Hussein; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Natural killer cells; Acute Myeloid Leukemia; immunotherapy; HDC IL-2; NKG2A; NK education; SNPs; NK activating receptors; HLA class I;

    Abstract : Numerous studies have revealed that natural killer cells have fundamental roles as effector cells in myeloid leukemias. Thus, understanding NK cell-related biomarkers that influence clinical outcome are warranted. READ MORE

  5. 8. Who is killing whom? Hantaviruses vs programmed cell death

    Author : Shawon Gupta; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hantaviruses belong to the Bunyaviridae family of negative stranded RNA viruses. They carry a tri-segmented genome and consist of four structural proteins. The four structural proteins are two glycoproteins Gn and Gc, a nucleocapsid (N) protein and an RNA-dependent RNA-polymerase. READ MORE

  6. 9. Immunological and clinical long-term effects of idiotype vaccination in multiple myeloma patients

    Author : Amir Osman Abdalla; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Idiotype; vaccination; multiple myeloma; T cell response;

    Abstract : In spite of the promising results shown by new anti-myeloma agents, multiple myeloma (MM) remains incurable and additional therapy to overcome the inevitable disease recurrence is greatly needed. Immunotherapy is currently under evaluation as a novel alternative or complementary therapy in many cancer types. READ MORE

  7. 10. Resident T cells in human skin : functional heterogeneity and clinical implications

    Author : Stanley Sing Hoi Cheuk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The skin forms a critical barrier against the external environment and is therefore frequently challenged by infections and subjected to immune-mediated diseases as well as malignancies. The Tissue-Resident Memory T (TRM) cell is a subset of T cells that resides at sites of previous infection in the skin and other epithelial tissues. READ MORE