Search for dissertations about: "griseofulvin"

Found 3 swedish dissertations containing the word griseofulvin.

  2. 1. Centrosome aberrations and tumor development

    Author : Kaoru Fujioka; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Centrosome; cervical carcinoma; adrenocortical tumor; tetraploidization; p53; griseofulvin; 13-cis-retinoic acid.;

    Abstract : The transformation of a normal cell to a tumor cell is a result of a failure somewhere in a complicated system of coordination, checkpoints and control mechanisms of inhibitors and activators working as triggers and transactivators of genes of importance for cell cycle progression. In the present thesis, the focus is on an important function that controls the segregation of the chromosomes during cell division to the next generation of two daughter cells. READ MORE

  4. 2. The effects of solid state properties on solubility and "in vitro" dissolution behaviour of suspended sparingly soluble drugs

    Author : Mitra Mosharraf; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The solubility and dissolution behaviour of hydrophobic and hydrophilic sparingly soluble drugs is discussed in this thesis. The roles of varying particle dimensions, disordered (amorphous) solid structures and the coexistence of amorphous and crystalline phases, especially on the surfaces of particles with a crystalline core, are evaluated in this context. READ MORE

  5. 3. Studies on structure and mechanism at formation of solid solutions and solid dispersions of hydrophobic drugs in polymers

    Author : Marie Wulff; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Physical and Inorganic Pharmaceutical Chemistry; fysikalisk och oorganisk farmaceutisk kemi;

    Abstract : The aim of the studies was to investigate the structures formed and mechanisms involved, when a hydrophobic drug is dispersed in a polymer carrier. The effect of different additives, like surfactants and cyclodextrins, was evaluated. The dispersions were prepared by the melting method. READ MORE