Search for dissertations about: "growth arrest"

Showing result 1 - 5 of 154 swedish dissertations containing the words growth arrest.

  1. 1. Improving cyanobacteria productivity: From theory to assay

    Author : Kiyan Shabestary; Elton P. Hudson; Daniel Ducat; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; metabolic engineering; growth-coupling; growth-arrest; cyanobacteria; CRISPRi; CRISPRi library; flux balance analysis; genome-scale model; butanol; lactate; isoprene; Biotechnology; Bioteknologi;

    Abstract : Bio-based production of biochemicals and biofuels holds great promises for the transition towards a more sustainable society. With increasing levels of carbon dioxide (CO2) in the atmosphere, cyanobacteria stand apart as natural catalysts directly converting CO2 and light to product. READ MORE

  2. 2. The Role of Stat1 in Retinoic Acid-induced Myelomonocytic Differentiation of Human Leukemia Cells

    Author : Anna Dimberg; Ivo Touw; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Stat1; ATRA; U-937; myeloid; differentiation; cell cycle; growth arrest; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : All-trans retinoic acid (ATRA), a biologically active metabolite of vitamin A, is a powerful inducer of terminal differentiation and growth arrest of several myeloid cell lines in vitro. Although the efficacy of ATRA as an anti-cancer drug has been demonstrated by the successful treatment of acute promyelocytic leukemia (APL), knowledge concerning the molecular mechanisms directing ATRA-induced differentiation and cell cycle arrest of myeloid cells is lacking. READ MORE

  3. 3. Diversification of TGF-β Signaling in Homeostasis and Disease

    Author : Michael Vanlandewijck; Aristidis Moustakas; Carl-Henrik Heldin; Steven Dooley; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-β; signaling; SIK; EMT; polarity; Notch; ALK5; p21; growth arrest; Smurf; Smad7; receptor; SNF1LK; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : With the dawn of metazoans, the ability of cells to communicate with each other became of paramount importance in maintaining tissue homeostasis. The transforming growth factor β (TGF-β) signaling pathway, which plays important roles during embryogenesis and in the adult organism, signals via a heterodimeric receptor complex consisting of two type II and two type I receptors. READ MORE

  4. 4. Cellular and molecular responses of periodontal connective tissue cells to Actinobacillus actinomycetemcomitans cytolethal distending toxin

    Author : Georgios N. Belibasakis; Sotirios Kalfas; Ulf H. Lerner; Anders Johansson; Veli-Jukka Uitto; Umeå universitet; []
    Keywords : Medical sciences; Actinobacillus actinomycetemcomitans; cytolethal distending toxin; periodontal connective tissue cells; localized aggressive periodontitis; growth arrest; bone resorption; receptor activator of NF-κB ligand; osteoprotegerin; pro-inflammatory cytokines; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; odontologi; Odontology;

    Abstract : Actinobacillus actinomycetemcomitans is present in elevated proportions and numbers in dental bacterial biofilms of patients with localized aggressive periodontitis. This variant of periodontal disease, occurring in adolescents and young adults, is characterized by rapid and severe destruction of the connective tissues and bone supporting the teeth, eventually culminating in tooth loss. READ MORE

  5. 5. Regulatory Effects of TGF-β Superfamily Members on Normal and Neoplastic Thyroid Epithelial Cells

    Author : Åsa Franzén; Paschalis Sideras; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; activin; BMP; cadherin; carcinoma; cell cycle arrest; dedifferentiation; EGF; growth inhibition; invasion; Smad; TGF-β; thyroid; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Thyroid growth and function is partly regulated by growth factors binding to receptors on the cell surface. In the present thesis, the transforming growth factor-β (TGF-β) superfamily members have been studied for their role in regulation of growth and differentiation of both normal and neoplastic thyroid epithelial cells. READ MORE