Search for dissertations about: "growth hormone deficiency"

Showing result 16 - 20 of 46 swedish dissertations containing the words growth hormone deficiency.

  2. 16. Prader-Willi syndrome : diagnosis and effects of growth hormone treatment

    Author : Ann Christin Lindgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA methylation test; genomic imprinting; glucose intolerance; growth hormone; Prader Willi syndrome; respiratory function;

    Abstract : Prader-Willi syndrome (PWS) is a rare neurogenetic disorder characterised by hypotonia (especially pronounced in the perinatal period) with "failure to thrive", hypogonadism, hypoventilation, dysmorphic features, final short stature and mental retardation. From the age of 2 years hyperphagia develops leading to obesity if the caloric intake is not limited. READ MORE

  4. 17. Life without thyroid hormone receptors

    Author : Sten Göthe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Thyroid hormone (TH) has many important functions during development and in the adult individual. It reaches its target cells via the blood system and binds its receptor (TR) located within the cell nucleus where the receptor regulates target genes. This hormone-mediated gene regulation is a finely tuned interplay of numerous parameters. READ MORE

  5. 18. Insulin and growth hormone : regulation of adipocyte metabolism during infancy and childhood

    Author : Ashraf Fawzy Kamel; Karolinska Institutet; Karolinska Institutet; []
    Keywords : human; rat; development; adipocytes; lipolysis; lipogenesis; glucose transport GLUT1; GLUT4; insulin; insulin receptor; growth hormone; growth hormone receptor microdialysis; obesity; Prader-Willi syndrome;

    Abstract : The aim of the present investigation was to investigate the role of insulin and growth (GH) in adipose tissue metabolism during development. Lipolysis and lipogenesis were studied in isolated adipocytes from humans and rats of various ages. READ MORE

  6. 19. Regulation of postnatal neurogenesis and brain angiogenesis by thyroid hormone

    Author : Jenny Liqun Zhang; Göteborgs universitet; []
    Keywords : thyroid hormone; neurogenesis; angiogenesis; SVZ OB; hippocampus; neural stem cells; endothelial cells; astrocytes;

    Abstract : Thyroid hormone (TH), which is secreted by the thyroid gland, exerts significant effects on the central nervous system (CNS), especially during development, so that delayed treatment of perinatal hypothyroidism results in severe cognitive retardation. Continuous postnatal neurogenesis occurs throughout adulthood in the subventricular zone (SVZ) of the lateral ventricle wall and in the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampal formation. READ MORE

  7. 20. Insulin-like growth factor-I deficiency, insulin sensitivity, and glucose metabolism

    Author : Klas Ekström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In children and adolescents, growth hormone (GH) and insulin-like growth factor-I (IGF-I) act in concert to stimulate linear growth; however, the effects on glucose metabolism are in opposition. GH increases insulin resistance by lipolysis. READ MORE