Search for dissertations about: "grs"

Showing result 1 - 5 of 18 swedish dissertations containing the word grs.

  2. 1. Genetics of Diabetes Subtypes. Characterization of novel cluster-based diabetes subtypes

    Author : Dina Mansour Aly; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Precision medicine; Diabetes Subclassification; genome-wide association studies; GWAS; genetic risk scores; GRS; chronic kidney disease; CKD; diabetic kidney disease; DKD; Estimated glomerular filtration rate; eGFR; ANDIS; diabetes; diabetics;

    Abstract : BACKGROUND: Type 2 diabetes (T2D) has been reproducibly clustered into five subtypes based on six-clinical variables; age at diabetes onset, body mass index (BMI), Glutamic acid decarboxylase autoantibodies (GADA), glycated hemoglobin (HbA1c) and insulin secretion and resistance estimated as HOMA2B and HOMA2IR derived from fasting glucose and Cpeptide. These subtypes have different disease progression and risk of complications. READ MORE

  4. 2. Fault tolerant control in flexible manufacturing systems

    Author : Torbjörn Andréasson; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; fault tolerant systems; distributed computing; factory automation; configuration; algorithms; flexible manufacturing systems FMS ; general recursiva system GRS ; computer intergrated manufacturing CIM ; data structures;

    Abstract : .... READ MORE

  5. 3. Genetic and lifestyle influences on memory, brain structure, and dementia

    Author : Beata Ferencz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This doctoral thesis investigated genetic, inflammatory, and lifestyle influences on cognition, brain structure, and dementia. The influence of TOMM40 polymorphisms (Study I), a PICALM, BIN1 and CLU genetic risk score (GRS; Studies II, III), and inflammatory cytokines (Study IV) was assessed, as well as potential interactions with physical activity (Studies II-IV). READ MORE

  6. 4. Identification of genetic biomarkers for the risk prediction of recurrent venous thromboembolism. Risk prediction of recurrent VTE

    Author : Abrar Ahmad; Allmänmedicin och klinisk epidemiologi; []
    Keywords : Recurrent venous thromboembolism; Genetic risk score; Multibiomarker;

    Abstract : Background: Venous thromboembolism (VTE) is the third most frequent life-threatening cardiovascular disease with an annual incidence rate of 1-2 per 1000 person-years. After the diagnosis for primary VTE, about 20-30% patients develop a recurrence within 5-years. READ MORE

  7. 5. Genetic Determinants of Obesity in Relation to Diet, Weight Gain and Mortality

    Author : Gull Rukh; Diabetes - kardiovaskulär sjukdom; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genetic variants; copy number variants; genetic risk score; BMI; gene-diet interactions; annual weight change; substantial weight gain; sugar-sweetened beverages; mortality; Mendelian randomization;

    Abstract : Obesity is one of the major health concerns that has reached epidemic proportions globally. It is generally believed to be a result of interactions between genetic and environmental factors. READ MORE