Search for dissertations about: "gtn"
Showing result 1 - 5 of 7 swedish dissertations containing the word gtn.
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1. Glyceryl Trinitrate Distribution and the "Remarkable Tolerance"
Abstract : To study the distribution of glyceryl trinitrate (GTN), a gas chromatographic method was developed for simultaneous determination of GTN and its dinitrate metabolites in 'plasma and tissues. The distribution of GTN and 1 ,3-g1yceryl dinitrate (1,3-GDN) and 1,2-glyceryl dinitrate (1,2-GDN) was studied in GTN tolerant and nonto1erant rats. READ MORE
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2. Sympathetic function in cardiac disorders.Upon cardio-renal sympathetic activity and effects of nitroglycerin in human heart failure
Abstract : This study explores pathophysiological mechanisms and prognostic implications of sympathetic activation in patients with atherosclerotic renovascular hypertension (RVH) and with chronic heart failure (CHF). Hitherto, it is unknown whether cardiac sympathetic activation is present in patients with RVH, the presence of which could relate to the increased cardiovascular mortality observed in this disorder. READ MORE
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3. Nitric oxide generation from nitroglycerin and other no-donors measured in the lung and studies on nitrate tolerance in the cardiovascular system
Abstract : Nitroglycerin (GTN) and compounds referred to as nitrovasodilators or NOdonors are frequently used in the treatment of ischemic heart disease. The common mode of action for these drugs is liberation of nitric oxide (NO). Nitric oxide evokes relaxation of smooth muscle through activation of guanylate cyclase with subsequent formation of eGMP. READ MORE
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4. Nitric oxide : An ally in extracorporeal circulation?
Abstract : Many complications associated with heart surgery are due to the negative effects of extracorporeal circulation (ECC). Some of these complications may be attributed to ECC-induced activation of inflammation and coagulation pathways. READ MORE
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5. Inorganic and organic nitrates as sources of nitric oxide
Abstract : Inorganic nitrate (NO3-) and nitrite (NO2-) have generally been considered stable inactive end products of nitric oxide (NO) or unwanted residues in the food chain. While several recent studies surprisingly demonstrate that nitrite is reduced to bioactive NO in blood and tissues, the more stable anion nitrate is still considered to be inert. READ MORE