Search for dissertations about: "gtp hydrolysis"

Showing result 1 - 5 of 21 swedish dissertations containing the words gtp hydrolysis.

  2. 1. Characterizing Elongation of Protein Synthesis and Fusidic Acid Resistance in Bacteria

    Author : Srihari Nagendra Ravi Kiran Koripella; Suparna Sanyal; Daniel Wilson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Elongation factor-G; FusB; GTP; Staphylococcus aureus; Escherichia coli and Fusidic acid; Molecular Biology; Molekylärbiologi;

    Abstract : Protein synthesis is a highly complex process executed by the ribosome in coordination with mRNA, tRNAs and translational protein factors. Several antibiotics are known to inhibit bacterial protein synthesis by either targeting the ribosome or the proteins factors involved in translation. READ MORE

  4. 2. Ribosomal translocation in real time : Method development to Applications

    Author : Chang-il Kim; Suparna Sanyal; Martin Ott; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ribosome; EF-G; pyrene mRNA; aminoglycoside; ribosomal protein; GTP hydrolysis; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : Translational elongation is the process in which the ribosome adds one amino acid at a time to the nascent peptide chain. As the ribosome elongates the peptide chain by 14 - 20 amino acids per second and performs hundreds of such cycles per protein, ‘elongation’ is one of the most crucial steps in translation. READ MORE

  5. 3. Mechanisms for control of nucleoside triphosphate hydrolysis. Effects of DNA and RNA co-factors

    Author : Bertil Macao; Göteborgs universitet; []
    Keywords : ATPase; GTPase; SRP; Ffh; FtsY; SRP RNA; OBP; UL9; oriS; oriS*; HSV-1; helicase.;

    Abstract : In energetically unfavourable biological processes "protein machines" utilize chemical energy from the hydrolysis of high-energy phosphate bonds. Thus, the hydrolysis of a nucleoside triphosphate (NTP) to nucleoside diphosphate (NDP) with the release of free orthophosphate results in a liberation of energy. READ MORE

  6. 4. The Protein Traffic on the Ribosome : The Mechanism and Regulation of Protein Synthesis in Prokaryotes

    Author : Andrey Zavialov; Måns Ehrenber; Venki Ramakrishnan; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; yellow; ribosome; translation; Gagarin; nobel prize; Biokemi; Biochemistry; Biokemi;

    Abstract : The aim of this work was to understand the molecular mechanism of translation and the mechanism of translation termination, in particular. Cleavage of peptidyl-tRNA and peptide release terminates translation of mRNA on the ribosome. In prokaryotes, three release factors (RFs) are involved in this process. READ MORE

  7. 5. Elongation factor 2: A key component of the translation machinery in eukaryotes : Properties of yeast elongation factor 2 studied in vivo

    Author : Galyna Bartish; Odd Nygård; Suparna Sanyal; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Elongation factor 2; yeast; ribosome; phosphorylation; Switch I; site-directed mutagenesis; functional complementation; Cell biology; Cellbiologi; cellbiologi; Cellbiology;

    Abstract : Synthesis of proteins is performed by the ribosome, a large ribonucleoprotein complex. Apart from the ribosome, numerous protein factors participate in this process. Elongation factor 2 (eEF2) is one of these factors. eEF2 is an essential protein with a mol. READ MORE