Search for dissertations about: "guinea pig"

Showing result 16 - 20 of 101 swedish dissertations containing the words guinea pig.

  2. 16. Neogenesis and alloxan toxicity in pancreatic islets, with special reference to the transplanted human β-cell

    Author : Björn Tyrberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Alloxan; β-cell; diabetes; differentiation; growth; insulin secretion; nephrectomy; ob ob; pancreatic islet; transplantation; guinea-pig human; mouse; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The aim of this work was to study whether adult human pancreatic β-cells have the capacity to proliferate in culture and after transplantation to the renal subcapsular space of mice. An immunosuppressive regimen for human islet discordant xenotransplantation to mice was designed. READ MORE

  4. 17. Predictive testing for contact allergy : comparison of some guinea pig and mouse protocols including dose-response designs

    Author : Helen Wahlkvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : contact allergens; contact allergy; cumulative contact enhancement test; dose-response; evaluation; Freund s complete adjuvant test; guinea pig maximization test; local lymph node assay; mouse ear swelling test; patch test; predictive testing; statistical analysis;

    Abstract : Contact allergy (delayed hypersensitivity) may develop as a result of skin exposure to contact allergens (haptens) and can lead to allergic contact dermatitis. The purpose of this study was to evaluate some predictive animal test methods for contact allergens. READ MORE

  5. 18. Hereditary susceptibility to inner ear stress agents studied in heterozygotes of the German waltzing guinea pig

    Author : Åsa Skjönsberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : age-dependent hearing loss; cisplatin; DPOAE; efferent system; gender; gentamicin; noise trauma; ototoxic drugs; protection;

    Abstract : The German waltzing guinea pig is a strain of animals expressing deafness and severe balance disorders already at birth. The mutation arose spontaneously in a breeding facility in Germany and as the affected animals show a characteristic waltzing behavior, the strain is named the German waltzing guinea pig. READ MORE

  6. 19. Elimination of circulation IgA and IgS immune complexes : An experimental study in mice, rats and guinea pigs

    Author : Anders Johansson; Ann Kari Lefvert; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Immune complexes were formed between dinitrophenyl- (DNP-) conjugated human serum albumin (HSA) and anti-DNP antibodies (monoclonal mouse IgA or polyclonal rabbit IgG). Blood clearance and tissue distribution of intravenously injected labelled antigen and immunecomplex preparations were studied in mice, rats and guinea pigs. READ MORE

  7. 20. Characterization of cochlear degeneration in the inner ear of the German waltzing guinea pig : a morphological, cellular, and molecular study

    Author : Zhe Jin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cochlea; Deafness; Embryonic development; Inner ear; Melanocyte; Phenotype; Recessive genes; Recycling; Stria vascularis.;

    Abstract : The German waltzing guinea pig is a new strain of animals with yet unknown gene mutation(s) displaying recessively inherited cochleovestibular impairment. The homozygous animals (gw/gw) are deaf already at birth and display Wpical waltzing behavior throughout life. READ MORE