Search for dissertations about: "gw3965"
Showing result 1 - 5 of 7 swedish dissertations containing the word gw3965.
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1. The antiproliferative role of the liver X receptors in breast and colorectal cancer
Abstract : The liver X receptors (LXRα and LXRβ) are members of the nuclear receptor superfamily of ligand activated transcription factors and have functions as regulators of lipid and glucose metabolism, as well as inflammatory response. In recent years, several reports have demonstrated an important role of LXRs in the control of cell proliferation. READ MORE
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2. LXR regulation of hepatic gene expression and pituitary dependent hormones
Abstract : The liver X receptors (LXRs) are ligand activated transcription factors involved in the regulation of metabolic genes. LXRs are considered potential drug targets to treat metabolic disorders, however, unwanted side effects, as revealed from rodent studies, include increased lipogenesis in the liver and increased plasma triglyceride levels. READ MORE
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3. Novel aspects of metabolic regulation and inflammation in human adipocytes
Abstract : The significance of adipose tissue and obesity has been recognized in numerous pathologies. However, the mechanisms behind this connection are not yet completely understood. READ MORE
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4. Beyond Th1 and Treg : intestinal T helper cells in disease and tolerance
Abstract : The human intestinal tract is not only one of the largest organs by surface area in our bodies but also harbors the greatest number of immune cells. These cells are crucial for maintaining tolerance towards the various food and microbial antigens and mounting protective inflammatory responses towards invading pathogens. READ MORE
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5. Studies of LXR and CIDEA function in human adipocytes
Abstract : Obesity, defined as a body mass index of 30 or above, is the result of an imbalance of energy intake and energy expenditure. In the last decade, the obesity prevalence has truly reached epidemic proportions with major effects on public health. READ MORE