Search for dissertations about: "hPreP"

Found 5 swedish dissertations containing the word hPreP.

  2. 1. Functional and structural studies of the Presequence protease, PreP

    Author : Hans G Bäckman; Elzbieta Glaser; Per Gardeström; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Presequence Protease; PreP; AtPreP; hPreP; Biochemistry; biokemi;

    Abstract : AtPreP (Arabidopsis thaliana Presequence Protease) is a zink metallooligopeptidase that is dually targeted to both mitochondria and chloroplasts. In these organelles it functions as a peptidasome that degrades the N-terminal targeting peptides that are cleaved off from the mature protein after protein import, as well as other unstructured peptides. READ MORE

  4. 2. Mitochondria in Alzheimer's Disease : The Presequence Protease and Mitochondria-Associated ER Membranes

    Author : Catarina Moreira Pinho; Elzbieta Glaser; Paolo Bernardi; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s Disease; Mitochondria; Mitochondria-associated ER membranes; human Presequence Protease; Biochemistry; biokemi;

    Abstract : Alzheimer’s disease (AD) is one of the most prevalent age-related neurodegenerative disorders and the accumulation of the amyloid-β peptide (Aβ) in the temporal lobe has been implicated in the pathology of AD. Synaptic transmission in neuronal cells is a highly energy dependent process, which relies on the presence and proper function of mitochondria. READ MORE

  5. 3. The Mitochondrial Peptidasome, PreP, relation to Alzheimer Disease

    Author : Nyosha Alikhani; Elzbieta Glaser; Doron Rapaport; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; biokemi;

    Abstract : Amyloid-β (Aβ) is the toxic peptide implicated in the pathogenesis of Alzheimer Disease (AD). Accumulation of Aβ has been shown in brain mitochondria from AD patients and AD mice models. The occurrence of Aβ in the mitochondrial matrix leads to free radical generation and apoptosis in neurons. READ MORE

  6. 4. Association studies on susceptibility genes in Alzheimer disease

    Author : Behnosh Fakhri Björk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Our results support the involvement of genetic variants in IDE; TFAM and COL25A1 in AD cases from Sweden; whereas; it does not for PITRM1.;

    Abstract : Alzheimer disease (AD) is the most common form of dementia in the elderly. Due to the complexity of AD, it has been difficult to find genetic risk factors predisposing to disease. To date, three genes (APP, PSEN1 and PSEN2) with disease causing genetic variants have been reported for the rare early onset monogenic forms of AD. READ MORE

  7. 5. Dual Targeting of Proteins to Mitochondria and Chloroplasts

    Author : Anna-Karin Berglund; Elzbieta Glaser; Ophry Pines; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; biokemi;

    Abstract : The vast majority of mitochondrial and chloroplastic proteins are nuclear encoded, synthesized in the cytosol and imported into the respective organelle using an N-terminal extension, the targeting peptide (TP). After import into the organelle, the TP is cleaved off and degraded by the Presequence protease (PreP). READ MORE