Search for dissertations about: "hTERT"
Showing result 16 - 20 of 30 swedish dissertations containing the word hTERT.
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16. Glioblastoma multiforme in the microscope: Diagnostic features of importance for prognosis and treatment
Abstract : Glioblastoma multiforme (GBM) is the most malignant and also the most common form of brain tumour in humans. The overall aim of this thesis was to investigate morphological and diagnostics features in human GBM that may be of importance for prognosis and treatment. READ MORE
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17. Epstein-Barr virus (EBV) latent membrane protein (LMP) 2A
Abstract : Epstein-Barr virus (EBV) is a ubiquitous human herpes virus which infects more than 90% of individuals in the population and is causally implicated in lymphoid and epithelial malignancies. Virus invades oropharyngeal mucosa and establishes latency in memory B lymphocytes. READ MORE
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18. p53 functional loss by mutation and p53 antagonizing proteins during tumor development
Abstract : p53 is the most common target for genetic alterations in human cancers. Inactivation of wild type p53 function by point mutation, deletion or complexing with antagonizing proteins such as MDM2 and DNA tumor viral oncoproteins, is frequently found in human and rodent tumors. READ MORE
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19. Expression and activity of Myc network proteins during cell cycle progression and differentiation
Abstract : Transcription factors of Myc network are the key regulators of cell proliferation, cell death and differentiation. Identified as a transforming oncogene, myc is the driving force of a variety of human cancers, and inactivation of myc in tumors can cause their rapid regression. READ MORE
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20. Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia
Abstract : A therapeutic strategy that may potentially delay progression or prevent relapse of B-cell chronic lymphocytic leukemia (B-CLL), is anti-leukemic vaccine therapy. This thesis focuses on comparing different strategies for loading antigen on dendritic cells (DC) with the aim of delineating the most effective antigen presentation platform for stimulating anti-leukemic T cells. READ MORE