Search for dissertations about: "hTERT"
Showing result 21 - 25 of 30 swedish dissertations containing the word hTERT.
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21. Studies on the mechanisms of carcinogenesis and cancer cell death
Abstract : Gastric cancer is the second most common cause of cancer-related mortality in the world. The mechanisms of gastric carcinogenesis are not fully elucidated. READ MORE
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22. p16INK4A and p15INK4B in senescence, immortalization and cancer : gene transfer by adenovirus vectors
Abstract : The astrocytic gliomas are the most common form of brain tumors in humans. The malignant progression from low grade (astrocytoma, grade II) to high-grade (glioblastoma multiforme, grade, IV) astrocytomas is well documented and is accompanied by an increasing number of genetic aberrations. READ MORE
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23. Novel mechanisms in depression: focus on telomere biology and epigenetic regulation
Abstract : Depression is a complex disorder with an average lifetime prevalence from 11.1% to 14.6%. It causes serious disability and is a significant public health problem worldwide. READ MORE
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24. Pheochromocytoma and abdominal paraganglioma : clinical and genetic aspects
Abstract : Pheochromocytomas and abdominal paragangliomas are rare catecholamine producing tumours arising from sympathoadrenal paraganglia located within and outside of the adrenal medulla, respectively. The great majority of tumours are benign and cured by surgery. READ MORE
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25. Roles of Myc and Mad in cell cycle and apoptosis
Abstract : The Myc network proteins are key mediators in regulation of cell growth, differentiation and apoptosis. They are basic region hehx-loop-helix/leucine zipper (bHLH/Zip) transcription factors that require hetero-dimerization with Max for specific DNA binding Mad family members are expressed primarily in differentiated tissues where they recruit histone deacetylase complexes via the mSin3 interaction domain (SID) to repress transcription of target genes and prevent cell growth In contrast, members of the Myc family activate target gene transcription by recruitment of histone acetyltransferases to their transcriptional activation domain (TAD), inducing proliferation and S phase entry. READ MORE