Search for dissertations about: "haloperidol d1"

Found 5 swedish dissertations containing the words haloperidol d1.

2. 1. Effects of antipsychotics on GABA neurons in the basal ganglia of the rat

   Author : Jiang Yu; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; antipsychotics; γ-aminobutyric acid; glutamic acid decarboxylase; basal ganglia; entopeduncular nucleus; vacuous chewing movements; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

   Abstract : Antipsychotics are used in the treatment of psychosis and, based on their propensities to induce extrapyramidal side effects (EPS), are divided into typical (haloperidol) and atypical (clozapine) subtypes. The incidence of EPS, arises from an imbalance in the neurotransmission between two majorGABAergic pathways of the basal ganglia that connect the striatum directly to the entopeduncular nucleus (EP) and the substantia nigra reticulata or indirectly via the globus pallidus and the subthalamic nucleus. READ MORE

4. 2. Novel mechanism of action of antipsychotic drugs : effects on neuropeptides in rat brain

   Author : Susanne H M Gruber; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Schizophrenia; D-amphetamine; Antipsychotic drugs; Neurotensin; Neuropeptide Y; Rat brain; Microdialysis;

   Abstract : Schizophrenic patients have been reported to have lower concentrations of neurotensin (NT)-like immunoreactivity (-LI) in their cerebrospinal fluid (CSF) that normalize after treatment with antipsychotic drugs. Schizophrenic patients also had higher CSF concentrations of neuropeptide Y (NPY)-LI compared to controls, thus involvement of NPY in the disease has also been suggested. READ MORE

5. 3. Up-regulation of dopamine D₂ receptors : in vitro and in vivo studies

   Author : Maria Wanderoy; Eliassitet Eriksson; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

   Abstract : In the central nervous system (CNS) dopaminergic and dopaminoceptive neurons have the ability to respond to variations in dopamine levels by for example adjusting their dopamine receptor levels. One of the most well known phenomena in this respect is that long-term blockade of D2 receptors with antipsychotic drugs leads to an increase in striatal D2 receptor density of experimental animals as well as of schizophrenic patients as measured in both post-mortem studies and in vivo positron emission tomography studies of brain. READ MORE

6. 4. Mode of action of asenapine vs. other antipsychotic drugs : an experimental analysis

   Author : Olivia Frånberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Antipsychotic drugs (APDs) are used in the treatment of schizophrenia and manic or mixed episodes associated with bipolar I disorder. Generally, the so-called atypical APDs, such as clozapine, may in contrast to typical APDs improve not only positive, but also negative symptoms and some aspects of cognitive impairment associated with schizophrenia. READ MORE

7. 5. Modulation of prefrontal glutamatergic transmission and 'atypicality' of antipsychotic drugs

   Author : Åsa Konradsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The glutamate hypothesis of schizophrenia suggests a relationship between hypoactive NMDA receptor-mediated glutamatergic transmission and the pathophysiology of schizophrenia. Previous results have demonstrated that atypical (e.g. clozapine, risperidone, and olanzapine), but not typical (e. READ MORE