Search for dissertations about: "haloperidol"

Showing result 1 - 5 of 25 swedish dissertations containing the word haloperidol.

  2. 1. Dopamine D2 and D3 receptors. Studies on transduction mechanisms and on the role of a D3 gene polymorphism

    Author : Monika Hellstrand; Göteborgs universitet; []
    Keywords : dopamine; dopamine D2 receptor; dopamine D3 receptor; transduction; CHO cells; partial agonism; inverse agonism; arachidonic acid; prostaglandin E2; cAMP; haloperidol; -3-PPP; PNU-99194A; polymorphism; personality;

    Abstract : The neurotransmitter dopamine has been implicated in the pathophysiology of, e.g., Parkinson s disease and schizophrenia, and dopamine receptor-active compounds are commonly employed therapeutically in these and other disorders. READ MORE

  4. 2. Pharmacokinetics of haloperidol and clozapine with pharmacodynamic considerations

    Author : Yi-fang Cheng; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  5. 3. Drug metabolic capacity in Koreans : CYP2D6 & CYP2C19 pheno- and genotype relationships in healthy volunteers and in patients

    Author : Hyung-Keun Roh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Drug metabolism; phenotype; genotype; CYP2D6; CYP2C 19; Korean; haloperidol; risperidone; omeprazole; gastric pH; gastrin; schizophrenia; patient.;

    Abstract : This thesis aimed to investigate the relationship between pheno- and genotype of two drugmetabolizing enzymes CYP2D6 and CYYP2C19 in Koreans. Population studies were conducted in healthy volunteers to obtain basic information on these two enzymes. READ MORE

  6. 4. Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs

    Author : Kerstin Håkansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adenosine A2A receptor; basal ganglia; cAMP-dependent protein kinase; clozapine; DARPP-32; dopamine D 2 receptor; extracellular signal-regulated protein kinases 1 and 2; extrapyramidal side effects; glutamate AMPA receptor; haloperidol; knockout mouse; phosphorylation; schizophrenia; tyrosine hydroxylase.;

    Abstract : The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. READ MORE

  7. 5. Clinical molecular imaging of schizophrenia

    Author : Mirjam Talvik; Karolinska Institutet; Karolinska Institutet; []
    Keywords : PET; D2 D3 receptors; 5HT2A receptors; antipsychotic drugs; schizophrenia; age effects; raclopride; FLB 457; M100907; clozapine; haloperidol; perphenazine; thalamus; cortex; striatum; PANSS;

    Abstract : The aim of this thesis was to examine pathophysiology and antipsychotic treatment of schizophrenia by using positron emission tomography (PET). The high affinity radioligand [11C]FLB 457 was used for determination of dopamine D2 receptor binding in the thalamus and the cortex of nine drug-naïve patients with schizophrenia and eight control subjects. READ MORE