Search for dissertations about: "haplotype sharing"
Showing result 1 - 5 of 10 swedish dissertations containing the words haplotype sharing.
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1. Statistical Methods for Genome Wide Association Studies
Abstract : This thesis focus on various statistical methods for analyzing Genome Wide Association data. The thesis include four papers, three of them considers the analysis of complex traits, and the last one a method for analyzing mendelian traits. READ MORE
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2. Long QT syndrome in Sweden : founder effects and associated cardiac phenotypes
Abstract : Background: We aimed to increase the knowledge regarding the familial arrhythmogenic disorder Long QT Syndrome (LQTS) and its recessive variant Jervell and Lange-Nielsen Syndrome (JLNS) in Sweden, including prevalences and clinical phenotypes. A specific focus was directed towards two KCNQ1 mutations –p.Y111C and p. READ MORE
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3. Genetic studies of stroke in Northern Sweden
Abstract : Stroke is a common disorder of later life with a complex etiology, including both environmental and genetic risk factors. The inherited predisposition is challenging to study due to the complexity of the stroke phenotype. READ MORE
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4. Candidate gene analyses and genome-wide screens in multiple sclerosis
Abstract : Specific disease causing mutations have been identified for many disorders. Most of these disorders are of Mendelian origin and there have been very few successful attempts in the genetic dissection of complex traits. READ MORE
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5. Long QT syndrome : studies of diagnostic methods
Abstract : Background: The Long QT Syndrome (LQTS) is a hereditary heart disease with risk of malignant ventricular arrhythmia and sudden cardiac death. Despite our increased knowledge about genotype and phenotype correlation we still rely on the 12-lead ECG for assessment of the QT interval and the T-wave morphology for diagnosis and risk stratification. READ MORE