Search for dissertations about: "harman"

Found 5 swedish dissertations containing the word harman.

2. 1. Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain : Role of Neuromelanin and Cytochrome P450 for Toxicity

   Author : Anna Östergren; Eva Brittebo; Nils Gunnar Lindquist; Anne-Lie Svensson; Hans Tjälve; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; β-carboline; neuromelanin; norharman; harman; parkinsonism; Parkinson s disease; motoric impairment; behaviour; glia cells; substantia nigra; dopamine melanin; PC12 cells; ER stress; grp78; hsp90; cytochrome P450; CYP1A1; CYP1B1; blood-brain interfaces; 7; 12-dimethylbenz[a]anthracene; polycyclic aromatic hydrocarbon; endothelial cell; smooth muscle cell; bioactivation; Toxikologi; Toxicology; Toxikologi; Toxicology; toxikologi;

   Abstract : The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and thereby induce parkinsonism. MPTP is, however, not normally present in the environment whereas the ß-carbolines are present in cooked food and tobacco smoke. READ MORE

4. 2. Moral Reality. A Defence of Moral Realism

   Author : Caj Strandberg; Praktisk filosofi; []
   Keywords : HUMANIORA; HUMANITIES; HUMANIORA; HUMANITIES; epistemology; ideology; Praktisk filosofi; ideologi; kunskapsteori; metafysik; estetik; Morallära; Systematic philosophy; Moral science; Gilbert Harman.; Simon Blackburn; Michael Smith; J. L. Mackie; G. E. Moore; David Brink; Nicholas Sturgeon; moral explanation; argument from queerness; metaphysics; supervenience; fetishist argument; externalism; internalism; moral motivation; moral properties; open question argument; moral reason; moral disagreement; naturalism; reductionism; error-theory; Cornell realism; moral realism; non-cognitivism; meta-ethics; ethics; aesthetics;

   Abstract : The main aim of this thesis is to defend moral realism. In chapter 1, I argue that moral realism is best understood as the view that (1) moral sentences have truth-value (cognitivism), (2) there are moral properties that make some moral sentences true (success-theory), and (3) moral properties are not reducible to non-moral properties (non-reductionism). READ MORE

5. 3. Debunking Debunked? : Challenges, Prospects, and the Threat of Self-Defeat

   Author : Conrad Bakka; Jonas Olson; Eriksson Björn; Folke Tersman; Stockholms universitet; []
   Keywords : HUMANIORA; HUMANITIES; evolutionary debunking arguments; genealogical debunking; reliability challenge; third-factor explanation; non-naturalism; explanationism; sensitivity; safety; conditional debunking arguments; metanormative; metaepistemology; Philosophy; filosofi;

   Abstract : Metaethical debunking arguments often conclude that no moral belief is epistemically justified. Early versions of such arguments largely relied on metaphors and analogies and left the epistemology of debunking underspecified. Debunkers have since come to take on substantial and broad-ranging epistemological commitments. READ MORE

6. 4. Modifying Cooking Practices to Reduce the Formation of Heterocyclic Amines

   Author : Elna Hallgard; Avdelningen för livsmedel och läkemedel; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Livsmedelsteknik; Food and drink technology; cancer; frying; mutagens; beefburger; chicken; heterocyclic amines; cooking;

   Abstract : Commonly cooked meat dishes contain heterocyclic amines (HAs) at ng/g levels. HAs are animal carcinogens, form DNA adducts in human tissues, and have been associated with increased risk of cancer in epidemiological studies, and it is thus recommended that human intake be decreased. READ MORE

7. 5. Mitochondrial DNA mutations : brain developmental and ageing consequences, and possible treatments

   Author : Jaime M Ross; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Ageing is a complex process that involves cellular senescence, a gradual loss of tissue homeostasis, and decline in organ function. Abundant evidence implicates mitochondria in ageing suggesting: (i) accumulation of mitochondrial DNA (mtDNA) damage, (ii) progressive respiratory chain dysfunction, and (iii) increased reactive oxygen species production. READ MORE