Search for dissertations about: "heart hypertrophy"

Showing result 1 - 5 of 50 swedish dissertations containing the words heart hypertrophy.

  2. 1. Cardiac hypertrophy : transcription patterns, hypertrophic progression and extracellular signalling

    Author : Nina Gennebäck; Stellan Mörner; Anders Waldenström; Urban Hellman; Ali J Marian; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac hypertrophy; HCM; gene expression; OPLS-DA; multivariate dataanalysis; cardiomyocytes; exosomes; microvesicles; Medicine; medicin;

    Abstract : Background: The aim of this thesis was to study transcription patterns and extracellular signalling of the hypertrophic heart to better understand the mechanisms initiating, controlling and maintaining cardiac hypertrophy.Cardiac hypertrophy is a risk factor for cardiovascular morbidity and mortality. READ MORE

  4. 2. Hyaluronan and the receptor CD 44 in the heart and vessels : a study in normal and pathological conditions

    Author : Martin Hellström; Anna Engström-Laurent; Bengt Johansson; Lena Jonasson; Umeå universitet; []
    Keywords : hyaluronan; CD44; heart; Rat; cardiac hypertrophy; artery; vein; human; Medicine; medicin;

    Abstract : Tissues are not solely composed of cells. The extracellular matrix is important for the cell well-being and cell-cell communication. The glycosaminoglycan hyaluronan (HYA) is a widely distributed extracellular matrix (ECM) component. READ MORE

  5. 3. Myocardial metabolism in experimental infarction and heart failure

    Author : Truls Råmunddal; Göteborgs universitet; []
    Keywords : Myocardial metabolism; Heart failure; Myocardial infarction; Lipotoxic heart disease; Apolipoprotein B; Arrhythmias; Cardiac reserve; Creatine metabolism;

    Abstract : Abstract The heart is an organ heavily dependent on exogenous lipids for the oxidative production of adenosine-triphosphate (ATP) and therefore maintenance of normal cellular energy homeostasis. However, high energy flux organs such as the heart must closely match lipid import and utilization or otherwise lipids will accumulate in the cardiomyocytes. READ MORE

  6. 4. An epidemiological perspective on heart and lung weight in cardiac and intoxication deaths

    Author : Torfinn Beer; Carl Johan Wingren; Anders Eriksson; Britt-Marie Stålnacke; Kimberly Molina; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heart weight; lung weight; organ weight; autopsy; forensic pathology; Bayesian analysis; cardiac hypertrophy; fatal intoxication; Forensic Medicine; rättsmedicin;

    Abstract : The main purpose of a medico-legal autopsy is to determine the cause and manner of death. A forensic pathologist makes assessments of this using several sources of information, one of which is the discrepancy between measured organ weight and reference values. READ MORE

  7. 5. About hyaluronan in the hypertrophic heart : studies on coordinated regulation of extracellular matrix signalling

    Author : Urban Hellman; Anders Waldenström; Stellan Mörner; Anna Engström-Laurent; Lena Jonasson; Umeå universitet; []
    Keywords : hyaluronan; hyaluronan synthases; gene expression; extracellular matrix; cardiac hypertrophy; rat wistar; male ; cardiomyocytes; growth factors; fibroblasts; microvesicles; exosomes; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. READ MORE