Search for dissertations about: "heat shock protein"

Showing result 6 - 10 of 121 swedish dissertations containing the words heat shock protein.

  2. 6. The Interaction Between the Chaperonin GroEL and Human Carbonic Anhydrase II : Protein Folding and Stability Studies

    Author : Malin Persson; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; carbonic anhydrase; protein folding; protein stability; chaperone; GroEL; folding mechanism; site-directed spinlabeling; electron paramagnetic resonance EPR ;

    Abstract : The presence of GroEL/ES during the refolding of human carbonic anhydrase II was found to increase the yield of active enzyme from approx. 70 to approx. 100%. This chaperone action on the enzyme could be obtained by adding GroEL alone, and the time course in that case was only moderately slower than the spontaneous process. READ MORE

  4. 7. Combined structural methods to characterize an oligomeric small heat shock protein Hsp21

    Author : Gudrun Rutsdottir; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Small heat shock proteins; chaperones; crosslinking mass spectrometry; Stable isotope labeling; quantification; small angle X-ray scattering; cryo-electron microscopy; combined structural methods; plant stress;

    Abstract : Small heat shock proteins (sHsps) are found in all organisms and evolved early in the history of life, prior to the divergence of the three domains of life (Archaea, Bacteria, and Eukarya). Their malfunction is connected to several different diseases in humans, such as Alzheimer’s and Parkinson’s disease. READ MORE

  5. 8. Stress response regulation and protein aggregate inheritance in Caulobacter crescentus

    Author : Frederic Dominique Schramm; Kristina Jonas; Franz Narberhaus; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; stress; protein aggregation; cellular aging; molecular chaperones; heat shock response; DnaK; sigma factor; suppressor genes; DNA replication; starvation; Caulobacter crescentus; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Many stress conditions a cell encounters threaten the continuation of basic biological processes ultimately endangering its survival. Heat shock and antibiotic exposure can lead to a sudden surge of protein un- and misfolding, while nutrient starvation directly causes a lack of energy and molecular building blocks. READ MORE

  6. 9. The conserved methionines in the chloroplast small heat shock protein - Role in chaperone-substrate interactions and effects of methionine sulfoxidation on chaperone activity

    Author : Niklas Gustavsson; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Metabolism; Biochemistry; oxidative stress; thermostability; temperature stress; stress tolerance; sHsp; protein aggregation; molecular chaperone; Heat stress; methionine sulfoxidation; Biokemi; metabolism; Plant biochemistry; Växtbiokemi;

    Abstract : The chloroplast-localized small heat shock protein (sHsp) Hsp21 belongs to the family of alpha-crystallin like sHsps which form large oligomeric structures and protect partly unfolded aggregation-prone proteins against aggregation. The main focus for this thesis has been on the highly conserved methionines in Hsp21. READ MORE

  7. 10. Vaccine strategies based on mycobacterial heat shock protein 65

    Author : Maria Sundbäck; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mycobacteria; DNA vaccination; Hsp65; T cells; CD8 T cell epitopes;

    Abstract : Mycobacteria can infect macrophages and dendritic cells (DC), where they reside inside the endosomal compartment. The importance of CD4+ T cells in protective immunity against mycobacteria and other intracellular pathogens is well established, and for a long time these cells were thought to be the major defense in controlling an infection. READ MORE