Search for dissertations about: "heat shock proteins"

Showing result 6 - 10 of 85 swedish dissertations containing the words heat shock proteins.

2. 6. Pathophysiology of blood-brain barrier, brain edema and cell injury following hyperthermia : New role of heat shock protein, nitric oxide and carbon monoxide : an experimental study in rat using light and electron microscopy

   Author : Hari Shanker Sharma; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; blood-brain barrier; heat stress; hyperthermia; brain edema; serotonin; nitric oxide; carbon monoxide; heat shock protein; glial fibrillary acidic protein; myelin basic protein; opioids; histamine; catecholamines; naloxone; indomethacin; p-CPA; electron microscopy; immunocytochemistry; Cellbiologi; Cell biology; Cellbiologi; Human Anatomy; anatomi;

   Abstract : This thesis deals with the molecular mechanisms of hyperthermia induced brain damage in rats. The results clearly establish that hyperthermia caused by 4 h heat stress at 38° C is associated with a breakdown of the blood-brain barrier (BBB) permeability which seems to be instrumental in causing brain edema and cell injury. READ MORE

4. 7. Combined structural methods to characterize an oligomeric small heat shock protein Hsp21

   Author : Gudrun Rutsdottir; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Small heat shock proteins; chaperones; crosslinking mass spectrometry; Stable isotope labeling; quantification; small angle X-ray scattering; cryo-electron microscopy; combined structural methods; plant stress;

   Abstract : Small heat shock proteins (sHsps) are found in all organisms and evolved early in the history of life, prior to the divergence of the three domains of life (Archaea, Bacteria, and Eukarya). Their malfunction is connected to several different diseases in humans, such as Alzheimer’s and Parkinson’s disease. READ MORE

5. 8. Exploring small heat shock protein chaperones by crosslinking mass spectrometry

   Author : Wietske Lambert; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; cross-linking; mass spectrometry; protein-protein interactions; Hsp21; BS3; DTSSP; MALDI-TOF TOF; client protein; substrate; aggregation; unfolded protein; chaperone; Small heat shock protein; crosslinking;

   Abstract : Together with other molecular chaperones, small heat shock proteins are key components of the protein quality control system, which is comprised of several hundred proteins and acts to maintain proteome homeostasis in the cell. Small heat shock proteins bind unfolding proteins at an early stage, to prevent these from further unfolding and aggregating. READ MORE

6. 9. Vaccine strategies based on mycobacterial heat shock protein 65

   Author : Maria Sundbäck; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Mycobacteria; DNA vaccination; Hsp65; T cells; CD8 T cell epitopes;

   Abstract : Mycobacteria can infect macrophages and dendritic cells (DC), where they reside inside the endosomal compartment. The importance of CD4+ T cells in protective immunity against mycobacteria and other intracellular pathogens is well established, and for a long time these cells were thought to be the major defense in controlling an infection. READ MORE

7. 10. Mapping ultrastructural effects of proteotoxic stress on S. cerevisiae

   Author : Katharina Keuenhof; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; yeast; heat shock; stress; electron microscopy; ultrastructure; nuclear envelope budding;

   Abstract : Cells are the basic building blocks of any living being, whether the organism consists of only one, or many cells. The different cellular components interact with one another to maintain the viability of the cell. An essential element of cells are proteins – peptide chains folded into a specific conformation unique to every protein. READ MORE