Search for dissertations about: "hematology thesis"
Showing result 1 - 5 of 148 swedish dissertations containing the words hematology thesis.
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1. Haemophilia B - Diagnostic Insights, Genetic Aspects and Clinical Outcomes
Abstract : Haemophilia B (HB) is a rare inherited bleeding disorder caused by the deficiency of coagulation factor IX (FIX). The major clinical issues are bleedings, often targeting the joints, and the development of neutralising antibodies, i.e. inhibitors, to the FIX replacement therapy. READ MORE
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2. Haemophilia A - In pursuit of optimised outcomes via personalised treatment
Abstract : Haemophilia A (HA) is a hereditary bleeding disorder, characterised by deficiency of coagulation factor VIII (FVIII). Repeated joint bleeds can lead to permanent joint damage. FVIII replacement therapy has a high cost and can reduce but not completely prevent bleeding. READ MORE
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3. Aspects of Complement Activation in Thrombocytopenic Disorders
Abstract : The complement system is an essential effector of both innate and acquired immune responses. Due to its destructive potential, tight regulation is required. The contribution of complement has been associated with the pathogeneses in a wide range of diseases. READ MORE
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4. Programming Blood Cell Fates. Insights from Direct Lineage Conversion and Development
Abstract : Red blood cells (RBC) and platelets constitute the non-immune branch of the hematopoietic system and are responsible for the vital functions of transporting oxygen to the tissues and clotting blood vessel injuries, respectively. These cells are produced during embryonic development and throughout life through a process called hematopoiesis which is tightly regulated by extrinsic and intrinsic factors. READ MORE
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5. Identification of intrinsic regulators in normal and malignant human hematopoiesis. An RNA-interference approach
Abstract : Bildandet av blodceller, hematopoesen, utgår från ett litet antal av de så kallade hematopoetiska stamceller som sitter i vår benmärg. Dessa celler har förmågan att ge upphov till alla mogna blodcellstyper av de tre hematopoetiska linjerna, samtidigt som de genom celldelning bibehåller sin egna mängd. READ MORE