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Showing result 1 - 5 of 246 swedish dissertations matching the above criteria.

  2. 1. Identification of Unique Hematopoietic Stem Cell Properties

    Author : Jens Nygren; Lunds universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; Hematologi; extracellulära vätskor; Haematology; extracellular fluids; cell cycle; fusion; transdifferentiation; plasticity; Medicine human and vertebrates ; Medicin människa och djur ; quiescence; hematopoietic stem cell; self-renewal;

    Abstract : Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. READ MORE

  4. 2. Stem cell function and organ development : analysis of Lhx2 function in hematopoietic stem cells and eye development

    Author : Lina Dahl; Leif Carlsson; Jan-Ingvar Jönsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lhx2; hematopoietic system; hematopoietic stem cell; progenitor; embryonic stem cell; embryoid body; eye development; forebrain; eye field transcription factor; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

    Abstract : When a multicellular organism suffers damages to tissues/organs it heals itself by either substituting the lost cellular matrix by scar formation or by regenerating the lost tissue. Regeneration likely occurs by a recapitulation of the developmental process that formed the organ. READ MORE

  5. 3. Hematopoietic stem cell dynamics during regenerative stress

    Author : Anna Rydström; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoietic stem cell; transplantation; regeneration; stress;

    Abstract : .... READ MORE

  6. 4. Unravelling mechanisms of hematopoietic stem cell expansion

    Author : Kristijonas Zemaitis; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cell; UM171; RNAi RNA-interference ; Targeted protein degradation;

    Abstract : .... READ MORE

  7. 5. Hematopoietic stem and progenitor cells and potentials for application in fetal cell replacement therapy

    Author : Karina Liuba; Lund Obstetrik och gynekologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in utero hematopoietic cell transplantation; hematopoietic stem cell; multipotent progenitor; fetal therapy; heterotypic cell fusion;

    Abstract : Fetal cell replacement therapy or in utero hematopoietic cell transplantation (IUHCT) is proposed as a non-myeloablative alternative to bone marrow transplantation (BMT) for a number of inborn immunologic, hematologic and metabolic disorders. IUHCT represents the method through which variable amounts of natural or genetically modified hematopoietic cells can be transferred to the fetal recipient in hope of correcting the disorder and preventing postnatal permanent organ damage. READ MORE