Search for dissertations about: "hematopoietic stem cells"

Showing result 21 - 25 of 215 swedish dissertations containing the words hematopoietic stem cells.

  2. 21. The Role of Kit and Thrombopoietin in Regulation of Hematopoietic Stem Cells

    Author : Lina Thorén; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thrombopoietin; hematopoiesis; Thpo; c-kit; stem cells;

    Abstract : The hematopoietic stem cell (HSC) is postulated to be the ultimate hematopoietic precursor providing production of mature blood cells, and is characterized by a life long capacity for self-renewal and multilineage differentiation. In a healthy human, the HSC produces 1,000,000,000,000 cells per day, illustrating the high turnover within the hematopoietic system and the need for replenishments by HSCs. READ MORE

  4. 22. Live and Let Die : Critical regulation of survival in normal and malignant hematopoietic stem and progenitor cells

    Author : Pernilla Eliasson; Jan-Ingvar Jönsson; Mikael Sigvardsson; Urban Gullberg; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoietic stem cells; hypoxia; self-renewal; survival; acute myeloid leukemia; FLT3; Cell and molecular biology; Cell- och molekylärbiologi; Haematology; Hematologi;

    Abstract : The hematopoietic stem cell (HSC) is characterized by its ability to self-renew and produce all mature blood cells throughout the life of an organism. This is tightly regulated to maintain a balance between survival, proliferation, and differentiation. READ MORE

  5. 23. Consequences of Shb Deficiency on Hematopoietic Cell Function

    Author : Karin Gustafsson; Michael Welsh; Martin Bergö; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoiesis; hematopoietic stem cells; myeloid neoplasia; T cells; atopic dermatitis; cell signaling; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : The adaptor protein Shb has been implicated in the signaling of several tyrosine kinase receptors and previous studies have suggested a role for Shb in the signal transduction of T cells. Shb associates with the T cell receptor (TCR) and partakes in the signal propagation of activated T lymphocytes. READ MORE

  6. 24. Identification of Unique Hematopoietic Stem Cell Properties

    Author : Jens Nygren; Lunds universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; Hematologi; extracellulära vätskor; Haematology; extracellular fluids; cell cycle; fusion; transdifferentiation; plasticity; Medicine human and vertebrates ; Medicin människa och djur ; quiescence; hematopoietic stem cell; self-renewal;

    Abstract : Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. READ MORE

  7. 25. Pathways that govern hematopoietic stem cell fate

    Author : Matilda Billing; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : hematopoies; Hematopoietic stem cell; TGF beta; Smad signaling; GATA2; p57;

    Abstract : Hematopoietic stem cells (HSCs) compose a rare population of undifferentiated cells, residing in the bone marrow of adult individuals, ensuring life-long maintenance and replenishment of the blood system. This fantastic achievement is possible owing to two special characteristics of the HSCs: their ability to make copies of themselves (self-renew), and their capacity to differentiate to all lineages of the blood system. READ MORE