Search for dissertations about: "heme biosynthesis"
Showing result 1 - 5 of 25 swedish dissertations containing the words heme biosynthesis.
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1. Porphyrins and heme in microorganisms : Porphyrin content and its relation to phototherapy and antimicrobial treatments in vivo and in vitro
Abstract : One of the greatest threats to human health is increasing antimicrobial resistance among pathogens, and finding alternatives for treatment of bacterial infections is of highest importance together with a more controlled use of antibiotics. Porphyrins and heme have both been shown to be a promising class of compounds for inactivation of bacteria; porphyrins by their excellent properties to act as a photosensitizer, and heme by its importance as an iron source during a bacterial infection in vertebrates. READ MORE
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2. Synthesis of hemes found in heme-copper oxidases of Bacillus subtilis
Abstract : The last step of aerobic respiration, the reduction of dioxygen to water, is catalysed by terminal oxidases. These oxidases can be divided into two unrelated families, the heme-copper oxidases and the cytochrome bd-type oxidases. These enzymes contain two or more heme molecules as prosthetic groups. READ MORE
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3. Ferrochelatase and Magnesiumchelatase: Metal chelation studied with mutants
Abstract : Magnesium chelatase and ferrochelatase are two very important enzymes, which are involved in chlorophyll and heme biosynthesis, respectively. They both use protoporphyrin IX as substrate but magnesium chelatase inserts a magnesium ion whereas ferrochelatase inserts a ferrous ion. These two enzymes have been studied in this thesis. READ MORE
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4. Enzymatic metal-chelation by porphyrins
Abstract : This thesis deals with the structure and function of two different enzymes, ferrochelatase and magnesium chelatase, that catalyse similar reactions. When this work started, a three-dimensional model of ferrochelatase existed. Much was known about the enzyme, but some details remained unclear. READ MORE
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5. Structural and physicochemical studies on metal and porphyrin binding by the Bacillus subtilis ferrochelatase
Abstract : The enzyme ferrochelatase (EC 4.99.1.1) is the terminal enzyme in the biosynthetic pathway of heme b and catalyzes the insertion of Fe(II) into protoporphyrin IX. READ MORE