Search for dissertations about: "heme oxygenase-1"

Showing result 1 - 5 of 6 swedish dissertations containing the words heme oxygenase-1.

  2. 1. Oxidative stress-related factors in abdominal aortic aneurysm: potential clinical implications

    Author : Sakshi Vats; Allmänmedicin och klinisk epidemiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; abdominal aortic aneurysm AAA ; mitochondria; Heme; Oxidative stress; Genetics; Epigenetic;

    Abstract : Abdominal aortic aneurysm (AAA) is a mostly silent vascular disease, with a rupture-related mortality rate exceeding 80%. To aid in future diagnosis and prognosis efforts, the studies included in the present thesis have explored the role of specific oxidative stress-related factors in the context of AAA using two population-based cohorts: AAA screening cohort of 65-year-old males (n = 421) and the Malmö diet and cancer study (MDCS) (n = 25252). READ MORE

  4. 2. Response mechanisms of normal hematopoietic cells and leukemic cells to genotoxic agents and novel therapeutic strategies

    Author : Andreas Hedblom; Malmö Experimentell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cells; genotoxic damage; cell cycle; leukemia; heme oxygenase; differentiation;

    Abstract : Hematopoiesis is initiated by a rare population of hematopoietic stem cells (HSC) in the bone marrow (BM). HSCs give rise to red blood cells and white blood cells of myeloid and lymphoid lineages. READ MORE

  5. 3. Renal cell death in urinary tract infections : role of E. coli toxins

    Author : Ming Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Pyelonephritis; Escherichia coli toxins; ERK; LPA; cell death; carbon monoxide; hemolysin; nitric oxide; heme oxygenase-1; dexamethasone; kidney development;

    Abstract : Febrile urinary tract infections (UTI) are common bacterial illnesses in children. Several follow up studies have shown that 10-15 % of infants with pyelonephritis will develop permanent renal damage, i.e., renal scars, which in turn may lead to chronic diseases such as hypertension and renal insufficiency. READ MORE

  6. 4. Tumor instructed normal tissue : studies of potential extratumoral biomarkers and therapeutic targets in prostate cancer

    Author : Maria Nilsson; Sofia Halin Bergström; Anders Bergh; Kristian Pietras; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; biomarkers; tumor-instructed normal tissue; extra cellular matrix; macrophages; LOX; HO-1; MSMB; Pathology; patologi;

    Abstract : Prostate cancer is the most common cancer in men in Sweden and but luckily the majority of the patients will carry on their life without any consequences from the disease. Unfortunately, some will develop aggressive tumors and eventually die. READ MORE

  7. 5. Renal Ischemia/Reperfusion Injury in Diabetes : Experimental Studies in the Rat

    Author : Jan Melin; Bengt Rippe; Uppsala universitet; []
    Keywords : Medical sciences; diabetes mellitus; ischemia reperfusion; rat; end-stage renal disease; inflammation; fibrosis; hyaluronan; CD44; treatment; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Diabetes mellitus (DM) is one of the leading causes of end stage renal failure. An increased susceptibility to renal ischemia/reperfusion (I/R)-injury was found in DM rats. Unilateral renal ischemia for as short as 20 minutes led to an irreversible progressive injury in DM kidneys, whereas the injury in non-DM kidneys was almost reversible. READ MORE