Search for dissertations about: "heparan sulfate proteoglycans"

Showing result 1 - 5 of 39 swedish dissertations containing the words heparan sulfate proteoglycans.

  1. 1. Heparan Sulfate and Development A Study of NDST Deficient Mice and Embryonic Stem Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Katarina Holmborn; Uppsala universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell and molecular biology; heparan sulfate; proteoglycan; biosynthesis; N-deacetylase N-sulfotransferase; NDST; gene targeting; embryonic development; lung development; mast cells; Cell- och molekylärbiologi;

    Abstract : Heparan sulfate (HS) proteoglycans consist of sulfated HS chains covalently bound to core proteins. They are ubiquitously expressed, on the cell surface and in the extracellular matrix, throughout the body. READ MORE

  2. 2. Heparan Sulfate Biosynthesis – Clues from Knockout Mice

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johan Ledin; Uppsala universitet.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; heparan sulfate; biosynthesis; gene targeting; embryonic development; proteoglycans; NDST; N-deacetylase N-sulfotransferase; Cell- och molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi;

    Abstract : In the extracellular space, many specialized proteins are located to support cells and to mediate cell-cell signalling. One class of such molecules is heparan sulfate (HS) proteoglycans, which are proteins with different properties and locations but all of them decorated with long unbranched HS polysaccharide chains. READ MORE

  3. 3. Heparan Sulfate Proteoglycans in Brain Tumor Development

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Argyris Spyrou; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; pediatric brain tumors; heparanase; NDST1; heparan sulfate proteoglycans; CD24; glycosaminoglycan mimetics; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : Malignant brain tumors are aggressive neoplasms that remain challenging to treat in spite of their detailed molecular characterization. Both adults and children may suffer from brain tumors, which, if not lethal, can cause severe long-term and devastating side effects. READ MORE

  4. 4. Cellular design of heparan sulfate The NDST enzymes and their regulation

    University dissertation from Uppsala : Universitetsbiblioteket

    Author : Pernilla Carlsson; Uppsala universitet.; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; heparan sulfate; heparin; proteoglycan; NDST; PAPS; Golgi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi;

    Abstract : Heparan sulfate proteoglycans are proteins with long, unbranched heparan sulfate (HS) polysaccharide chains attached to them. They are found on cell surfaces and in basement membranes where they exert their action by interacting with a wide range of enzymes and signaling molecules and are thereby involved in a range of various processes both during embryonic development and in adult physiology. READ MORE

  5. 5. Heparan Sulfate in the Amyloidosis and Inflammation of Alzheimer’s Disease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Paul O'Callaghan; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; amyloidosis; amyloid-β; apolipoprotein E; astrocytes; glia; heparanase; heparan sulfate; heparan sulfate proteoglycans; microglia; neuroinflammation; Geriatrics; Geriatrik; Cellforskning; Cell Research; Neuroscience; Neurovetenskap; Pathology; Patologi;

    Abstract : Alzheimer’s disease (AD) is a neurodegenerative disorder, with extensive evidence implicating the misfolding, aggregation and deposition of the amyloid-β (Aβ) peptide as central to the pathogenesis. Heparan sulfate (HS) is an interactive glycosaminoglycan, attached to core proteins as HS proteoglycans (HSPGs). READ MORE