Search for dissertations about: "heparan sulfate proteoglycans"
Showing result 16 - 20 of 42 swedish dissertations containing the words heparan sulfate proteoglycans.
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16. Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans
Abstract : Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins (LDL) in the intima by chondroitin sulfate (CS)-rich proteoglycans (PG). READ MORE
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17. Syndecan - Regulation and Function of its Glycosaminoglycan Chains
Abstract : The cell surface is an active area where extracellular molecules meet their receptors and affect the cellular fate by inducing for example cell proliferation and adhesion. Syndecans and integrins are two transmembrane molecules that have been suggested to fine-tune these activities, possibly in cooperation. Syndecans are proteoglycans, i.e. READ MORE
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18. Proteoglycans, group IIA phospholipase A2, and lipoproteins.Potential involvement in atherogenesis
Abstract : Atherosclerosis is a multifactorial complex disease characterized by a focal accumulation of ApoB-100 containing lipoproteins, extracellular matrix (ECM), and cells in the arterial intima accompanied by an inflammatory reaction. In vivo and in vitro data supports the hypothesis that sulfated extracellular proteoglycans may be responsible for the selective retention of low density lipoproteins (LDL) in the arterial wall. READ MORE
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19. The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis
Abstract : A critical step in the development of atherosclerotic lesions appears to be the retention of low density lipoproteins (LDL) in the arterial wall, mediated by negatively charged proteoglycans (PG). Retained LDL is susceptible to modification and uptake by resident macrophages that are found in hypoxic sites in atherosclerotic lesions (with oxygen levels below 1%). READ MORE
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20. Glycosaminoglycan Biosynthesis in Zebrafish
Abstract : Proteoglycans (PGs) are composed of highly sulfated glycosaminoglycans chains (GAGs) attached to specific core proteins. They are present in extracellular matrices, on the cell surface and in storage granules of hematopoietic cells. READ MORE