Search for dissertations about: "heparan sulfate"

Showing result 11 - 15 of 98 swedish dissertations containing the words heparan sulfate.

2. 11. Regulation of Heparan Sulfate 6-O-Sulfation Patterns

   Author : Anh-Tri Do; Marion Kusche-Gullberg; Ulf Lindahl; Malcolm Lyon; Uppsala universitet; []
   Keywords : Biochemistry; Heparan Sulfate; Biosynthesis; 6-O-sulfation; 6-O-sulfotransferases; 6-O-endosulfatases; Nematostella; Biokemi;

   Abstract : Heparan sulfates (HSs) are linear, negatively charged polysaccharides composed of alternating hexuronic acid (glucuronic acid or iduronic acid) and glucosamine residues that can be substituted to varying degrees with sulfate groups. HS, localized in the extracellular matrix and on the surface of most cells, interacts with a large number of proteins. READ MORE

4. 12. N-Sulfation and Polymerization in Heparan Sulfate Biosynthesis

   Author : Jenny Presto; Lena Kjellén; Gunnar Pejler; Anders Malmström; Uppsala universitet; []
   Keywords : Cell and molecular biology; Heparan sulfate; N-deacetylase N-sulfotransferase; NDST; EXT1; EXT2; Biosynthesis; Cell- och molekylärbiologi;

   Abstract : Heparan sulfate (HS) is a glycosaminoglycan present in all cell types covalently attached to core proteins forming proteoglycans. HS interacts with different proteins and thereby affects a variety of processes. READ MORE

5. 13. Heparan sulfate dependent cell signaling and associated pathophysiology : Implications in tumorigenesis and embryogenesis

   Author : Tahira Batool; Jin-Ping Li; Aristidis Moustakas; Liliana Schaefer; Ingvar Ferby; Michael Welsh; Anders Malmström; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparanase; Glucuronyl-C5 epimerase; Heparan Sulfate; Heparin; Lung Cancer; Cancer cell Singling; TGF-Beta; BMP; VEGF; Notch Signaling; Tumor growth; Metastasis; embryonic development; Medical Biochemistry; Medicinsk biokemi;

   Abstract : Heparan sulfate proteoglycans (HSPGs) consist of a protein core to which several linear, negatively charged heparan sulfate (HS) chains are covalently attached. HSPGs are expressed on the cell surface and in the extra-cellular matrix (ECM) where they have diverse biological functions, for example co-receptor functions. READ MORE

6. 14. Modulation of Angiogenesis by Laminins and Heparan Sulfate

   Author : Lars Jakobsson; Lena Claesson-Welsh; Johan Kreuger; Elisabetta Dejana; Uppsala universitet; []
   Keywords : Molecular medicine; Embryonic stem; heparan sulfate; laminin; basement membrane; VEGFR-2; VEGF; endothelial cell; signaling; angiogenesis; vasculogenesis; embryoid body; Molekylärmedicin;

   Abstract : Blood vessels transport blood with essential nutrients and oxygen to the cells in our body. In a healthy adult, formation of new vessels (angiogenesis) occurs only in case of tissue repair and growth. READ MORE

7. 15. Understanding Heparan Sulfate Biosynthesis and Functional Implications of Heparanase

   Author : Tianyi Song; Dorothe Spillmann; Cathrine Merry; Uppsala universitet; []
   Keywords : Heparan sulfate; biosynthesis; heparanase; lipid metabolism; cancer; cell adhesion; apoptosis.; Molekylär medicin;

   Abstract : Heparan sulfate (HS) proteoglycans are present on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Heparanase is an endo-ß-glucuronidase that cleaves HS chains at internally located ß-glucuronidic linkages1. READ MORE