Search for dissertations about: "hepatic microcirculation"

Showing result 1 - 5 of 6 swedish dissertations containing the words hepatic microcirculation.

  2. 1. Factors influencing splanchnic microcirculation in animal models of endotoxaemia

    Author : Andreas Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Microcirculation;

    Abstract : Even though severe sepsis and septic shock therapy has improved in recent years, mortality remains high (22-50%). Disturbances in splanchnic organ homeostasis and increases in gut permeability have long been presumed to contribute to systemic inflammation and multiple organ dysfunction syndrome in critical illness and septic shock. READ MORE

  4. 2. Liver tissue characterization and influence of chemotherapy in liver surgery

    Author : Jan Nilsson; Lund Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal liver metastases; liver regeneration; incisional hernia; steatosis; hepatic microcirculation; diffuse reflectance spectroscopy; DRS; sidestream dark-field imaging; SDF; laser speckle contrast imaging; LSCI;

    Abstract : Background & Aims: Primary liver cancer is the second most common cause of death from cancer worldwide. In the western world, the majority of liver malignancies consist of colorectal metastases. Liver resection is the primary treatment for cure in liver tumor disease. READ MORE

  5. 3. Resection of colorectal liver metastases - Impact of preoperative chemotherapy

    Author : Sam Eriksson; Lund Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal liver metastases; Preoperative chemotherapy; Liver resection; Hepatic microcirculation; Sarcopenia;

    Abstract : Background Colorectal cancer is a leading cause of cancer related death worldwide. 20-30 % of patients will develop colorectal liver metastases (CRLMs). Surgical resection is the mainstay of treatment for CRLMs, and is often combined with perioperative chemotherapy, which can prolong progression-free survival after resection. READ MORE

  6. 4. Studies of pancreatic islet microcirculation and insulin secretion in normal and diabetic rats

    Author : Zhen Huang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : diabetes; islet; insulin; microcirculation; ethanol; blood flow; hypoglycemia; renin angiotensin system; statins;

    Abstract : Type 2 diabetes is increasing globally. The disease is characterized not only by hyperglycemia, but also by insulin resistance with attendant dyslipidemia, hypertension and endothelial dysfunction. These aberrations may result in macrovascular disease, and deeply impact the longevity and quality of life in diabetic patients. READ MORE

  7. 5. Regional fluxes of tissue plasminogen activator in porcine endotoxemia

    Author : Annette Nyberg; Göteborgs universitet; []
    Keywords : pig; endotoxin; tissue type plasminogen activator; plasminogen activator inhibitor; tumor necrosis factor ?;

    Abstract : Formation of fibrin clots in the microcirculation during severe sepsis contributes to organ failure, frequently involving the lungs and the splanchnic organs. Tissue type plasminogen activator, tPA, is the key activator of intravascular fibrinolysis with plasminogen activator inhibitor type-1, PAI-1, as its main inhibitor. READ MORE