Search for dissertations about: "hepatitis C virus"

Showing result 16 - 20 of 104 swedish dissertations containing the words hepatitis C virus.

  2. 16. On the outcome of antiviral therapy for hepatitis C virus genotype 2 or 3 infection

    Author : Åsa Alsiö; Göteborgs universitet; []
    Keywords : infectious diseases; virology; hepatitis c; treatment;

    Abstract : Abstract Approximately 80% of patients infected with HCV genotypes 2 or 3 achieve a sustained virological response (SVR), following 24 weeks of therapy with ribavirin and pegylated interferon (peg-IFN), but in light of considerable side effects and cost, shortened treatment duration without impaired efficacy is desirable. Thus, 382 genotype 2/3 infected patients were randomized in an investigator-initiated phase III study (NORDynamIC) evaluating the efficacy of 12 (short-term) vs. READ MORE

  4. 17. Epidemiology and clinical importance of GB virus C/hepatitis G virus

    Author : Robert Halasz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : GBV-C; HGV; prevalence; transmission; children; fulminant hepatic failure; clinical importance;

    Abstract : GB virus C (GBV-C) or hepatitis G virus (HGV) is a recently discovered enveloped RNA virus belonging to the Flaviviridae family. GBV-C/HGV has been suggested to be a causative agent of non-A-non-E hepatitis. However, several contradictory observations cast doubts that it actually causes hepatitis. READ MORE

  5. 18. Design and Synthesis of Acyclic and Macrocyclic Peptidomimetics as Inhibitors of the Hepatitis C Virus NS3 Protease

    Author : Anna Lampa; Anja Sandström; Youla Tsantrizos; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; hepatitis C virus; HCV; NS3 protease inhibitor; structure-activity relationship; phenylglycine; ring-closing metathesis; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Hepatitis C is a blood-borne disease affecting 130-170 million people worldwide. The causative agent, hepatitis C virus (HCV), infects the liver and is the major reason for chronic liver disease worldwide. The HCV NS3 protease, a key enzyme in the virus replication cycle, has been confirmed to be an important target for drug development. READ MORE

  6. 19. Immunological and Genetic Markers Predicting Treatment Outcome in Hepatitits C Virus Infection

    Author : Galia Askarieh; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IP-10; CXCL10; CD26; hepatitis C virus; interferon; ribavirin; treatment; IL28B;

    Abstract : Hepatitis C is a blood-borne infection caused by the hepatitis C virus (HCV). A chronic infection, which develops in most infected subjects, may lead to liver cirrhosis with ensuing liver dysfunction and liver cancer. READ MORE

  7. 20. Posttransplant Lymphoproliferative Disorders : Studies of Epstein-Barr Virus, Regulatory T Cells and Tumor Origin

    Author : Amelie Kinch; Karlis Pauksens; Gunilla Enblad; Eva Baecklund; Harald Holte; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PTLD; Lymphoma; Epstein-Barr Virus; EBV DNAemia; FoxP3; Treg; Microenvironment; Cell of Origin; Recipient; Transplantation; Immunosuppression; Hepatitis C; Survival; Medicinsk vetenskap; Medical Science;

    Abstract : Epstein-Barr virus (EBV) infects almost all humans and establishes lifelong latency in B cells. Posttransplant lymphoproliferative disorder (PTLD) is a rare but serious complication after transplantation triggered by immunosuppression and often related to EBV infection. READ MORE