Search for dissertations about: "hepatobiliary system"

Found 4 swedish dissertations containing the words hepatobiliary system.

  1. 1. The Hepatobiliary Transport of Rosuvastatin In Vivo

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ebba Bergman; Hans Lennernäs; Ulf Bondesson; Jack Cook; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rosuvastatin; Biliary excretion; Transport inhibition; Pharmacokinetics; Drug-drug interactions; Hepatobiliary transport; Organic anion transporting polypeptide; OATP; Statins; Gemfibrozil; Cyclosporine; Imatinib; Rifampicin; Canalicular transport; Sinusoidal transport; Hepatic uptake; Hepatic extraction; PHARMACY Biopharmacy; FARMACI Biofarmaci; Biopharmaceutics; biofarmaci;

    Abstract : In vivo studies of hepatobiliary disposition are challenging. The hepatobiliary system is complex, as its physiological localization, complex cellular structure with numerous transporters and enzymes, and the interindividual variability in protein expression and biliary flow will all affect the in vivo disposition of a drug under investigation. READ MORE

  2. 2. Quantitative Evaluation of Contrast Agent Dynamics in Liver MRI

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Nils Dahlström; Örjan Smedby; Torkel Brismar; Anders Ynnerman; Carsten Thomsen; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liver; spleen; hepatobiliary system; liver function; MRI; DCE-MRI; Gd-EOBDTPA; Gd-BOPTA; pharmacokinetic; hepatocyte; relaxivity.; MEDICINE; MEDICIN;

    Abstract : The studies presented here evaluate the biliary, parenchymal and vascular enhancement effects of two T1-shortening liver-specific contrast agents, Gd-BOPTA and Gd-EOB-DTPA, in Magnetic Resonance Imaging (MRI) of healthy subjects and of patients.Ten healthy volunteers were examined with both contrast agents in a 1. READ MORE

  3. 3. Magnetic Resonance Imaging of the Hepatobiliary System Using Hepatocyte-Specific Contrast Media

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Nils Dahlström; Örjan Smedby; Torkel Brismar; Anders Ynnerman; Lennart Blomqvist; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE Physiology and pharmacology Radiological research Diagnostic radiology; MEDICIN Fysiologi och farmakologi Radiologisk forskning Diagnostisk radiologi;

    Abstract : There are two Gadolinium-based liver-specific contrast media for Magnetic Resonance Imaging on the market, Gd-BOPTA (MultiHance®, Bracco Imaging, Milan, Italy) and Gd-EOB-DTPA (Primovist®, Bayer Schering Pharma, Berlin, Germany). The aim of this study in two parts was to evaluate the dynamics of biliary, parenchymal and vascular enhancement using these contrast media in healthy subjects. READ MORE

  4. 4. Biopharmaceutical investigations of doxorubicin formulations used in liver cancer treatment Studies in healthy pigs and liver cancer patients, combined with pharmacokinetic and biopharmaceutical modelling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ilse R Dubbelboer; Hans Lennernäs; Erik Sjögren; Hartmut Derendorf; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug delivery system; in vivo release; PBPK modelling; hepatocellular carcinoma; doxorubicin; transarterial chemoembolization; drug disposition; Biofarmaci; Biopharmaceutics; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : There are currently two types of drug formulation in clinical use in the locoregional treatment of intermediate hepatocellular carcinoma (HCC). In the emulsion LIPDOX, the cytostatic agent doxorubicin (DOX) is dissolved in the aqueous phase, which is emulsified with the oily contrast agent Lipiodol® (LIP). READ MORE