Search for dissertations about: "hepatocellular"

Showing result 1 - 5 of 106 swedish dissertations containing the word hepatocellular.

2. 1. Tumor-stroma interactions in hepatocellular carcinoma

   Author : Nataša Pavlović; Femke Heindryckx; Jessica Maiers; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatocellular carcinoma; fibrosis; endoplasmic reticulum stress; unfolded protein response; platelets; P2Y12; Molekylär cellbiologi; Molecular Cellbiology; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Abstract : Hepatocellular carcinoma (HCC), a highly deadly primary liver cancer with a rising global incidence and limited therapeutic options, is characterized by a vicious cross-talk between the tumor and its surrounding hepatic stroma. The stromal environment, consisting of hepatic stellate cells (HSC), endothelial cells, resident and infiltrating macrophages and other immune cells, platelets and extracellular matrix (ECM) components, actively contributes to creating an ideal niche for tumor proliferation and invasiveness. READ MORE

4. 2. TGFβ and LXR signaling in hepatocellular carcinoma

   Author : Claudia Bellomo; Aristidis Moustakas; Lars Holmgren; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Hepatocellular Carcinoma; high-throughput imaging; small molecules; epithelial plasticity; LXR; Snail; TGFβ; tumor suppression; reactive oxygen species; cancer-associated fibroblast; myofibroblast; Smad3; αSMA;

   Abstract : Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in the Asia-pacific regions, with its incidence expected to rise up to 22 million cases till 2020. Hepatocellular carcinoma etiology is mainly due to hepatitis B (HBV) and hepatitis C (HCV) infections, and to a lesser extent it is determined by the development of alcohol-driven cirrhosis and non-alcoholic steatohepatitis (NASH). READ MORE

5. 3. Prognostic factors and tumor treatments in hepatocellular cancer

   Author : Malin Sternby Eilard; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatocellular cancer; prognostication;

   Abstract : Background: Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. Prognosis is related to tumor burden, liver function, and performance status as well as treatment factors. Accurate prognostication is a requisite for optimal treatment decisions. READ MORE

6. 4. In vitro evaluation of formulations used in the treatment of hepatocellular carcinoma

   Author : Emelie Ahnfelt; Hans Lennernäs; Erik Sjögren; Niklas Axén; Jesper Østergaard; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug delivery system; Doxorubicin; Microgel; Emulsion; Hepatocellular carcinoma; Biofarmaci; Biopharmaceutics;

   Abstract : Hepatocellular carcinoma (HCC) causes ~ 600,000 deaths annually, making it the second most deadly cancer form. HCC is classified into five stages and for the intermediate HCC treatment, the two most commonly used drug delivery systems (DDSs) are lipiodol-based emulsions and drug-eluting beads. READ MORE

7. 5. Some epidemiological aspects of liver cirrhosis and hepatocellular carcinoma in Sweden

   Author : Juan Vaz; Allmänmedicin och samhällsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liver cirrhosis; Hepatocellular carcinoma; Epidemiology; Socioeconomic Status; Survival Analysis; Etiology; Sweden;

   Abstract : Background: Contemporary epidemiological studies examining incidence rates (IR) of cirrhosis and hepatocellular carcinoma (HCC) in Swedish populations are scarce. Cirrhosis and HCC are associated with a significant burden of health inequity and stigma. READ MORE