Search for dissertations about: "hernatopoietic stem cells"

Found 5 swedish dissertations containing the words hernatopoietic stem cells.

2. 1. Immune reconstitution after allogeneic hematopoietic stem cell transplantation

   Author : Brigitta Omazic; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Immune reconstitution; allogeneic haematopoietic stem cell transplantation; IgH gene expression; TcRVbeta gene expression; B lymphocytes; T lymphocytes; IGF-1 receptor; thyroid hormone receptor.;

   Abstract : After treatment with allogeneic hernatopoietic stem cell transplantation (HSCT) the patient suffers from a deficient immune system for at least 12 months or longer. During this period, the patient is susceptible to infections and if the state of immune deficiency is prolonged there is an increased risk of relapse of the underlying malignancy as well as development of secondary malignancies. READ MORE

4. 2. Multiparameter flow cytometry and minimal residual disease in patients with acute leukemia

   Author : Elisabet Björklund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Flow cytometry; immunophenotyping; Minimal Residual Disease; acute leukemia; hernatopoietic stem cells;

   Abstract : The investigation of minimal residual disease (MRD) with multiparameter flow cytometry (FC) immunophenotyping has proven to be a powerful approach for disease monitoring in patients with acute leukemia (AL). This technique mainly relies on the identification of minor leukemic cell populations that can be discriminated from their normal counterparts on the basis of phenotypic aberrancies observed at diagnosis. READ MORE

5. 3. Ephrins off the beaten path

   Author : Johan Holmberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The Orchestration of cell-cell interactions is crucial to the developing embryo and the adult organism. Intercellular communication is to a large extent controlled by signalling events downstream of receptor tyrosine kinases (RTKs). Ligands for RTKs are often soluble and confer long distance information to the receptor expressing cell. READ MORE

6. 4. Apoptosis in myelodysplastic syndromes : effects of hemopoietic growth factors

   Author : Ramin Tehranchi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Increased apoptosis of hernatopoietic progenitors is a hallmark of myelodysplastic syndromes (MDS) and results in ineffective hematopoiesis. Erythroid apoptosis is thought to be the main mechanism underlying the severe anemia observed in the low-risk subgroups, refractory anemia (RA) arid RA with ringed sideroblasts (RARS). READ MORE

7. 5. Studies on mechanisms of busulphan cytotoxicity and pharmacokinetics : with special reference to liposomal busulphan

   Author : Zuzana Hassan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Busulphan is an alkylating agent currently used in conditioning regimen prior to stem cell transplantation (SCT). High dose therapy with busulphan has been shown to contribute to transplantation-related toxicities, such as veno-occlusive disease (VOID) and interstitial pneumonia, Previous pharmacodynamic studies have attempted to define a target systemic exposure to busulphan, and thresholds for different side effects. READ MORE