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Showing result 1 - 5 of 50 swedish dissertations matching the above criteria.

2. 1. On the Versatility of Microwave-Assisted Chemistry : Exemplified by Applications in Medicinal Chemistry, Heterocyclic Chemistry and Biochemistry

   Author : Kristina M. Orrling; Mats Larhed; Fredrik Almqvist; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microwave-assisted chemistry; malaria; aspartic protease; plasmepsin; PfPM4; PmPM4; PoPM4; PvPM4; inhibitor; unsaturated lactone; unsaturated lactam; unsaturated amide; lactam; Bestmann s ylide; ionic liquid; polymerase chain reaction; thermophilic enzyme; Pharmaceutical chemistry; Läkemedelskemi; Organic synthesis; Organisk syntes; Biochemistry; Biokemi; Biochemistry; biokemi;

   Abstract : Today, the demand for speed in drug discovery is constantly increasing, particularly in the iterative processes of hit validation and expansion and lead optimization. Irradiation with microwaves (MWs) has been applied in the area of organic synthesis to accelerate chemical reactions and to facilitate the generation of new chemical entities since 1986. READ MORE

4. 2. Structure-Property Relationships of Iron N-Heterocyclic Carbene Complexes : Synthesis, Characterization and Application

   Author : Valtýr Freyr Hlynsson; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; photoredox catalysis; photovoltaics; photosensitizer; N-heterocyclic carbene NHC ; BHAS; synthesis; Organometallic chemistry; structure-property relationship; coordination chemistry; heteroleptic iron complexes; geometry; photophysics;

   Abstract : Resulting from the general availability of first-row transition metals, compared to their second- and third-row counterparts, photosensitizers (PSs) based on metals like iron have gained interest as candidates to enable photochemistry from solar energy, a largely underutilized energy source. Iron complexes equivalent to other metal complexes, currently being used as PS, do lack some of the advantageous properties required to challenge the established PSs. READ MORE

5. 3. Development of Aerobic Oxidative N-Heterocyclic Carbene Catalysis via Multistep Electron Transfer and its Application

   Author : Anton Axelsson; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; dihydropyranone; Michael addition; kinetics.; aerobic oxidation; acylation; N-heterocyclic carbene; green chemistry; Organocatalysis; electron transfer mediator; asymmetric synthesis;

   Abstract : Oxidation reactions are ubiquitous in synthetic chemistry, but generally suffer from formation of large amounts of potentially toxic byproducts. Aerial oxygen represents an ideal oxidant since it is inexpensive, non-toxic and only forms water as a byproduct. READ MORE

6. 4. C1 Building Blocks: New Approaches for Thiomethylations and Esterification

   Author : Marcus Söderström; Luke R. Odell; Anders Karlén; Vittorio Pace; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Borontrifluoride; Dimethylsulfide; Thiomethylation; Methylthioethers; Dithioacetalation; Methyl-Dithioacetals; Friedel-Crafts; Diarylmethanes; Defluorination; Methyl-Dithioesters; Thioamides; Diazomethane; Esterification; Medicinal Chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

   Abstract : The thioether motif is found in numerous pharmaceuticals. The simplest form of this motif, the methyl-thioether is similarly found in many biologically active compounds and has exhibited many advantageous properties. The installation of the thiomethyl moiety can be troublesome due to the toxicity and malodor of small sulfur reagents. READ MORE

7. 5. Construction of Five-Membered Heterocyclic Compounds via Radical Cyclization

   Author : Stefan Berlin; Lars Engman; Mario D. Bachi; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; radical; cyclization; carbonylation; melatonin; pyrrolidine; pyrrolidin-3-one; tetrahydrofuran-3-one; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Abstract : This thesis describes how radical cyclization chemistry can be applied for the construction of heterocyclic compounds.In the first part, a series of electron deficient α-phenylselenenylalkenes were prepared via a PhSeCl-addition/HCl-elimination sequence. READ MORE