Search for dissertations about: "high grade astrocytoma"

Showing result 1 - 5 of 7 swedish dissertations containing the words high grade astrocytoma.

2. 1. Cell-based models for studying paediatric high-grade gliomas

   Author : Susanna Larsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; paediatric brain tumour; glioblastoma; glioma stem cell; primary culture; xenograft tumour; zebrafish;

   Abstract : Brain tumours are the largest group of solid tumours in children and accounts for most cancer-related deaths. Astrocytoma is the largest group, representing almost half of the brain tumours, where high-grade glioma is one of the most devastating forms with very poor prognosis due to lack of efficient treatments. READ MORE

4. 2. 201Thallium SPECT; accuracy in astrocytoma diagnosis and treatment evaluation

   Author : Kristina Källén; Helsingborg Kliniska Vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : The aims of the studies included in this thesis were:• to investigate the reliability of 201thallium single photon emission computed tomography (201Tl SPECT) for preoperative diagnosis and histological staging of malignant astrocytomas in comparison with CT; • to develop a method for quantification of cerebral thallium uptake, and to evaluate the quantitative measurement in comparison with CT, for astrocytoma treatment follow-up purposes; • to compare quantitative 201Tl SPECT and proton magnetic resonance spectroscopy (1H-MRS) with conventional MR imaging for astrocytoma monitoring, and to evaluate associations between change of morphological tumour characteristics during treatment and changes of cerebral thallium uptake and metabolic ratios. Results and conclusions:• High 201Tl-index, calculated as a ratio comparing tumour uptake to uptake in the contralateral hemisphere, is an indicator of highly malignant astrocytoma. READ MORE

5. 3. The LRIG-family: identification of novel regulators of ErbB signaling with clinical implications in astrocytoma

   Author : Jonas Nilsson; Håkan Hedman; Roger Henriksson; Maria Sibilia; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; astrocytic tumors; EGFR; ErbB; glioblastoma multiforme; LRIG; negative regulation.; Oncology; Onkologi;

   Abstract : Astrocytic tumors are the most common malignancies of the central nervous system, accounting for more than 60% of all primary brain tumors. The prognosis for high grade astrocytoma patients is dismal and there is no curative treatment, today. READ MORE

6. 4. Transcription factors PROX1 and p53 in cancer development

   Author : Tamador Elsir; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The majority of malignant brain tumors in adults are astrocytic gliomas. These are classified into four malignancy grades according to the World Health Organization (WHO) criteria, including grade I pilocytic astrocytoma, grade II astrocytoma, grade III anaplastic astrocytoma and grade IV glioblastoma. READ MORE

7. 5. Neural Progenitor Cells in malignancy and injury of the brain. A Trojan Horse fro gliomas?

   Author : Karin Staflin; CNS Genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serologi; transplantation; Immunologi; Medicine human and vertebrates ; Medicin människa och djur ; Immunology; serology; Glioma; sub ventricular zone; neural progenitor cell;

   Abstract : Gliomas are neoplasms arising in the central nervous system (CNS), and constitute the most common primary brain tumor. They are classified depending on the grade and morphology, from grade I, pilocytic astrocytoma, to grade IV, glioblastoma multiforme (GBM). Glioblastomas constitute a great challenge in treatment due to their disseminating nature. READ MORE