Search for dissertations about: "high-throughput screen"

Showing result 1 - 5 of 60 swedish dissertations containing the words high-throughput screen.

2. 1. Bipolar electrochemistry for high throughput screening applications

   Author : Sara Munktell; Fredrik Björefors; Maria Hahlin; Tautgirdas Ruzgas; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; bipolar electrochemistry; electrodeposition; corrosion; screening; gradients; recycling; gold nanoparticles; Scanning Droplet Cell; Hard x-ray photoelectron spectroscopy; pitting corrosion; Kemi med inriktning mot materialkemi; Chemistry with specialization in Materials Chemistry;

   Abstract : Bipolar electrochemistry is an interesting concept for high throughput screening techniques due to the ability to induce gradients in a range of materials and their properties, such as composition, particle size, or dopant levels, among many others. One of the key advantages of the method is the ability to test, create or modify materials without the need for a direct electrical connection. READ MORE

4. 2. Improved Techniques for High-Throughput Molecular Diagnostics

   Author : Mario Curcio; KTH; []
   Keywords : DNA; Molecular Diagnostics;

   Abstract : The amount of information derived from sequencing the humangenome is leading to an exponential increase in the rate atwhich genes and genetic disorders are mapped and characterized.As a consequence, the demand for genetic testing is alsodramatically increasing. READ MORE

5. 3. The p97 ATPase and the Drosophila Proteasome : Protein Unfolding and Regulation

   Author : Kristian Björk Grimberg; Patrick Young; Neus Visa; Lars Thelander; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; proteasome; ubiquitin; p97; unfolding; regulation; RNAi screen; high-throughput screen; cnc; basic leucine zipper; transcription factors; proteasome inhibition; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

   Abstract : For all living systems, there is a requirement to recycle and regulate proteins. In eukaryotic organisms this is accomplished by the proteasome. The p97 ATPase is another highly conserved and essential complex present throughout the eukaryotic cell. READ MORE

6. 4. Introducing weak affinity chromatography to drug discovery with focus on fragment screening

   Author : Minh-Dao Duong-Thi; Sten Ohlson; Brian Dymock; Linnéuniversitetet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affinity LC-MS; fragment-based drug discovery; fragment screening; high throughput; mass spectrometry; stereoisomer; enantiomer; thrombin; weak affinity chromatography; WAC; WAC-MS.; Biomedical Sciences; Biomedicinsk vetenskap; Biokemi; Biochemistry;

   Abstract : Fragment-based drug discovery is an emerging process that has gained popularity in recent years. The process starts from small molecules called fragments. One major step in fragment-based drug discovery is fragment screening, which is a strategy to screen libraries of small molecules to find hits. READ MORE

7. 5. Exploring the interplay between mRNA degradation and ribosome dynamics using high-throughput sequencing

   Author : Yujie Zhang; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Regulation of gene expression in response to fluctuating environments is essential for cellular survival. This regulation is multi-faceted, with mRNA abundance determined by both synthesis and decay. mRNA decay regulates transcript abundance, enabling swift transcriptomic adaptations. READ MORE