Search for dissertations about: "hindpaw withdrawal latency HWL"

Found 2 swedish dissertations containing the words hindpaw withdrawal latency HWL.

2. 1. Contribution of the sensory nervous system : an experimental study in the rat

   Author : Olle Löfgren; Karolinska Institutet; Karolinska Institutet; []
   Keywords : edema; hindpaw withdrawal latency HWL ; inflammation; microcirculation; scalding; sensory nervous system; sensory neuropeptide antagonists; sensory neuropeptides; thermal injury;

   Abstract : The pathophysiological background to burn induced inflammatory reactions is poorly understood and present therapy options are limited. A model of thermal injury was developed to enable investigations of the acute inflammatory reactions in the periphery as well as of the transmission of nociception at the spinal cord level. READ MORE

4. 2. Role of calcitonin gene-related peptide in nociception : interactions with substance P and opioids

   Author : Long-Chuan Yu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Calcitonin gene-related peptide CGRP ; CGRP8-37; CGRP-like immunoreactivity; carrageenan; dorsal horn; dorsal root ganglion DRG ; experimentally-induced inflammtion ß-funaltrexamine ß-FNA ; hindpaw withdrawl latency HWL ; hot-plate test; ;

   Abstract : This thesis presents a study of calcitonin gene-related peptide (CGRP) and its antagonist CGRP8-37 and the interactions with substance P and opioids on the transmission of presumed nociceptive information at the spinal cord level in the rat. Significant bilateral increases in hindpaw withdrawal latency (HWL) to heat and mechanical stimulation were induced dose-dependently by intrathecal administration of 5 or 10 but no 1 nmol of CGRP8-37. READ MORE