Search for dissertations about: "histatin 5"

Showing result 1 - 5 of 8 swedish dissertations containing the words histatin 5.

2. 1. Making sense of adsorption : Attempting to explain the adsorption of histatin 5 with models, metaphors, and machines

   Author : Kristin Hyltegren; Beräkningskemi; []
   Keywords : Intrinsically Disordered Proteins; histatin 5; adsorption; ellipsometry; Monte Carlo simulations; coarse graining; charge regulation;

   Abstract : This thesis summarises two studies in which the main purpose was to find out how and why the amount of the protein histatin 5 that adsorbs to negatively charged surfaces changes with pH and ionic strength. Histatin 5 is an intrinsically disordered saliva protein, and in the oral environment it adsorbs to tooth enamel. READ MORE

4. 2. Coarse-Grained Modelling of Protein Adsorption

   Author : Kristin Hyltegren; Beräkningskemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; intrinsically disordered proteins; histatin 5; fibrinogen; protein adsorption; nanotopography; ellipsometry; Monte Carlo simulations; Coarse-grained modelling; charge regulation;

   Abstract : The adsorption of proteins is a very common phenomenon, happening almost always when a protein solution comes into contact with a solid. However, it is far from always clear what the results of adsorption will be in terms of adsorbed amount, protein orientation, and protein conformation. READ MORE

5. 3. Fighting microbial infections with force fields: Evaluating conformational ensembles of intrinsically disordered proteins

   Author : Stephanie Jephthah; Beräkningskemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; molecular dynamics; force field; Monte Carlo; coarse-grained modeling; simulation; intrinsically disordered protein; histatin 5; small-angle x-ray scattering; circular dichroism; atomistic MD simulations; all-atom protein models;

   Abstract : The main goal of this compilation thesis has been to investigate the conformational ensemble of the intrinsically disordered protein (IDP) histatin 5 by using a mixture of experimental and computational techniques including, but not limited to, small-angle X-ray scattering (SAXS), circular dichroism (CD) spectroscopy, atomistic molecular dynamics (MD) simulations, and coarse-grained Monte Carlo (MC) simulations. Histatin 5 is a peptide of particular interest for two reasons. READ MORE

6. 4. Assessing Structural and thermodynamical properties of IDP's through Synchrotron X-ray Scattering and Monte Carlo Simulations

   Author : Carolina Cragnell; Beräkningskemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; intrinsically disordered proteins; histatin 5; β-casein; small angle x-ray scattering; Monte Carlo Simulations; coarse graining;

   Abstract : .... READ MORE

7. 5. Assessing the structural and dynamical properties of concentrated solutions of the disordered proteins Histatin 5 and its tandem repeat

   Author : Eric Fagerberg; Beräkningskemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Simulation; IDP; crowding;

   Abstract : Intrinsically disordered proteins are distinguished by a lack of distinct three-dimensional structure, existing instead as an ensemble of heterogenous structures. In this research, the effect of crowding on these proteins is investigated using a combined approach of experiment and computer simulation, mainly using coarse-grained simulation models to make simulation computationally feasible at the high concentration conditions crowding is displayed. READ MORE