Search for dissertations about: "histone acetylation"

Showing result 11 - 15 of 62 swedish dissertations containing the words histone acetylation.

  2. 11. Gene regulation during development by chromatin and the Super Elongation Complex

    Author : Olle Dahlberg; Mattias Mannervik; Peter Gergen; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila development; gene regulation; transcription; chromatin; P-TEFb; Super Elongation Complex; KDM4A; H3K36me3; H3K14ac; histone replacement; utvecklingsbiologi; Developmental Biology;

    Abstract : Developmental processes are carefully controlled at the level of transcription to ensure that the fertilized egg develops into an adult organism. The mechanisms that controls transcription of protein-coding genes ultimately ensure that the Pol II machine synthesizes mRNA from the correct set of genes in every cell type. READ MORE

  4. 12. Non-protein-coding RNA : Transcription and regulation of ribosomal RNA

    Author : Stefanie Böhm; Ann-Kristin Östlund Farrants; Brian McStay; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ribosomal RNA; non-coding RNA; ribosomal genes; rDNA gene; B-WICH; chromatin remodelling; histone modification; Cell Biology; cellbiologi;

    Abstract : Cell growth and proliferation are processes in the cell that must be tightly regulated. Transcription of ribosomal RNA and ribosomal biogenesis are directly linked to cell growth and proliferation, since the ribosomal RNA encodes for the majority of transcription in a cell and ribosomal biogenesis influences directly the number of proteins that are synthesized. READ MORE

  5. 13. Epigenetic Mapping in Type 2 Diabetes. Glucose-triggered histone modifications in various tissues

    Author : Bompada Pradeep; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; epigenetics; histone modifications; genome editing; ChIP-seq; RNA-seq; pancreatic islets; diabetic kidney disease; peripheral blood mononuclear cells; atherosclerosis;

    Abstract : Epigenetic modifications triggered by high glucose may predispose to diabetes risk by regulating gene expression activity. A growing body of evidence suggests that histone modification which is an essential component of epigenetic mechanism may play an important role in the development of type 2 diabetes (T2D) and its complications. READ MORE

  6. 14. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors

    Author : Steven Gray; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Liver Tumor; Histone Aceltylation; Gene expression; trichostatin A; Insulin-like growth factor axis; Comparative genomic hybridization; Spectral karyotyping;

    Abstract : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. READ MORE

  7. 15. Activity and mechanism of action of histone deacetylase inhibitors in synovial sarcoma

    Author : Limin Ma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Synovial sarcoma is a rare but aggressive paediatric soft tissue sarcoma that is driven by the genomic rearrangement t(X;18)(p11.2;q11.2). The resulting fusion protein, SS18- SSX, exhibits oncogenic properties through protein-protein interactions that alter gene transcriptions and chromatin remodelling. READ MORE